BCTC
Chemical Name: 4-(3-Chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-1-piperazinecarboxamide
Purity: ≥98%
Biological Activity
BCTC is an orally effective vanilloid receptor 1 (TRPV1 receptor) antagonist. Inhibits acid- and capsaicin-induced activation of rat TRPV1 receptors (IC50 values are 6.0 and 35 nM respectively). Displays analgesic properties in rat models of inflammatory and neuropathic pain. CNS penetrant.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. In vivo characterization in rat models of inflamma
Pomonis et al.
J.Pharmacol.Exp.Ther., 2003;306:387 -
N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. In vitro characterization and pharmacokinetic proper
Valenzano et al.
J.Pharmacol.Exp.Ther., 2003;306:377
Product Datasheets
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Citations for BCTC
The citations listed below are publications that use Tocris products. Selected citations for BCTC include:
2 Citations: Showing 1 - 2
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Elevated expression of transient receptor potential vanilloid type 1 in dorsal root ganglia of rats with endometriosis.
Authors: Lian Et al.
Mol Med Rep 2017;16:1920
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Ion channel TRPV1-dependent activation of PTP1B suppresses EGFR-associated intestinal tumorigenesis.
Authors: Lars Et al.
J Clin Invest 2014;124:3793-806
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