Bestatin
Chemical Name: N-[(2S,3R)-3-Amino-2-hydroxy-1-oxo-4-phenylbutyl]-L-leucine
Purity: ≥98%
Biological Activity
Bestatin is an aminopeptidase inhibitor (Ki = 0.001 - 90 mM); inhibits enkephalin metabolism and leukotriene A4 hydrolase. Inhibits tumor cell proliferation.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Effect of ubenimex (Bestatin) on the cell growth and phenotype of HL-60 and HL-60R cell lines: up- and down-regulation of CD13/aminopeptidase N.
Imamura and Kimura
Leuk.Lymphoma, 2000;37:663 -
Bestatin as an experimental tool in mammals.
Scornik and Botbol
Curr.Drug Metab., 2001;2:67 -
Bestatin, an inhibitor of aminopeptidase B, produced by actinomycetes.
Umezawa et al.
J.Antibiot., 1976;29:97
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