BigLEN (mouse)
Purity: ≥95%
Biological Activity
BigLEN (mouse) is a GPR171 agonist. ProSAAS-derived neuropeptide. Regulates food intake in mice. Inhibits the release of glutamate onto parvocellular neurons of the paraventricular nucleus in a process dependent upon activation of postsynaptic G proteins.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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ProSAAS-derived peptides are colocalized with neuropeptide Y and function as neuropeptides in the regulation of food intake.
Wardman et al.
PLoS.One., 2011;6:e28152 -
Neuropeptide PEN and its receptor GPR83: distribution, signaling, and regulation.
Mack et al.
ACS Chem.Neurosci., 2019;10:1884
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Citation for BigLEN (mouse)
The citations listed below are publications that use Tocris products. Selected citations for BigLEN (mouse) include:
1 Citation: Showing 1 - 1
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The GPR171 pathway suppresses T cell activation and limits antitumor immunity.
Authors: Richard D Et al.
Nat Commun 2021;12:5857
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