BIO 1211

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3
   WS Chen, Z Cao, S Sugaya, MJ Lopez, VG Sendra, N Laver, H Leffler, UJ Nilsson, J Fu, J Song, L Xia, P Hamrah, N Panjwani
   Nat Commun, 2016;7(0):11302.
2. Differential MSC activation leads to distinct mononuclear leukocyte binding mechanisms.
   Kota, Daniel J, DiCarlo, Bryan, Hetz, Robert A, Smith, Philippa, Cox, Charles, Olson, Scott D
   Sci Rep, 2014;4(0):4565.
3. Multiple activation sites of integrin α₄β₁ detected through their different affinities for a small molecule ligand.
   Chen et al.
   J.Biol.Chem., 1999;274:13167
4. Selective, tight-binding inhibitors of integrin α4β1 that inhibit allergic airway responses.
   Lin et al.
   J.Med.Chem., 1999;42:920
5. Discovery of trans-4-[1-[[2,5-Dichloro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetyl]-(4S)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid: an orally active, selective very late antigen-4 antagonist.
   Muro et al.
   J.Med.Chem., 2009;52:7974

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