BMS 688521

Catalog #: 4970
1 Citation Datasheet / COA / SDS

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BMS 688521 | CAS No. 893397-44-9 | Cell Adhesion Inhibitors

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Description: Potent inhibitor of the LFA-1/ICAM interaction

Chemical Name: 6-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4,4]non-7-yl]-3-pyridinecarboxylic acid

Purity: ≥98%

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Product Details

Citations (1)

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Biological Activity

BMS 688521 is a potent inhibitor of the LFA-1/ICAM-1 interaction (IC₅₀ values are 2.5 and 78 nM in HUVEC adhesion and mouse specific adhesion assays respectively). Inhibits eosinophil accumulation in the lungs in a mouse allergic eosinophilic lung inflammation model.

Technical Data

M.Wt:

536.37

Formula:

C₂₆H₁₉Cl₂N₅O₄

Solubility:

Soluble to 100 mM in DMSO

Purity:

≥98%

Storage:

Store at -20°C

CAS No:

893397-44-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Small molecule antagonist of leukocyte function associated antigen-1 (LFA-1): structure-activity relationships leading to the identification of 6-((5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]
Watterson et al.
J.Med.Chem., 2010;53:3814

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Citation for BMS 688521

The citations listed below are publications that use Tocris products. Selected citations for BMS 688521 include:

1 Citation: Showing 1 - 1

CDK8 Regulates Insulin Secretion and Mediates Postnatal and Stress-Induced Expression of Neuropeptides in Pancreatic β Cells.
Authors: Jing Et al.
Cell Rep 2019;28:2892-2904.e7

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