Home / Cyclin-dependent Kinase Inhibitors / BRD 6989

BRD 6989

Catalog #: 6438
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6438/50
6438/10
BRD 6989 | CAS No. 642008-81-9 | Cyclin-dependent Kinase Inhibitors
1 Image
Description: Cdk8 inhibitor; enhances IL-10 production

Chemical Name: 2-Amino-5,6,7,8-tetrahydro-6-methyl-4-(3-pyridinyl)-3-quinolinecarbonitrile

Purity: ≥97%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Binds and inhibits Cdk8 in complex with cyclin C (IC50 ~ 200 nM). Enhances IL-10 production in activated human and murine macrophages and dendritic cells (EC50 is approximately 1 μM for IL-10 production in bone marrow-derived dendritic cells). Also inhibits CDK19 in complex with cyclin C.

Technical Data

M.Wt:
264.33
Formula:
C16H16N4
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥97%
Storage:
Store at +4°C
CAS No:
642008-81-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells.
    Johannessen et al.
    Nat.Chem.Biol., 2017;13:1102

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citation for BRD 6989

The citations listed below are publications that use Tocris products. Selected citations for BRD 6989 include:

1 Citation: Showing 1 - 1

  1. Loss of Cyclin C or CDK8 provides ATR inhibitor resistance by suppressing transcription-associated replication stress.
    Authors: Stephen P Et al.
    Nucleic Acids Res  2021;

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for BRD 6989

There are currently no reviews for this product. Be the first to review BRD 6989 and earn rewards!

Have you used BRD 6989?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.