BRL 44408 maleate
Chemical Name: 2-[(4,5-Dihydro-1H-imidazol-2-yl)methyl]-2,3-dihydro-1-methyl-1H-isoindole maleate
Purity: ≥98%
Biological Activity
BRL 44408 maleate is a selective α2A-adrenoceptor antagonist (Ki = 1.7 nM and 144.5 nM at α2A and α2B-adrenergic receptors respectively). Increases hippocampal noradrenalin release following systemic administration.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
α2C-adrenoceptors mediate contractile responses to noradrenaline in the human saphenous vein.
Gavin et al.
Naunyn Schmiedebergs Arch.Pharmacol., 1997;355:406 -
α2A-But not α2B/C-adrenoceptors modulate noradrenaline release in rat locus coeruleus: voltammetric data.
Callado et al.
Eur.J.Pharmacol., 1999;366:35 -
Subtype-specificity of the presynaptic α2-adrenoceptors modulating hippocampal NE release in rat.
Kiss et al.
Brain Res., 1995;674:238 -
Novel α2-adrenoceptor antagonists show selectivity for α2A- and α2B-adrenoceptor subtypes.
Young et al.
Eur.J.Pharmacol., 1989;168:381
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Citations for BRL 44408 maleate
The citations listed below are publications that use Tocris products. Selected citations for BRL 44408 maleate include:
2 Citations: Showing 1 - 2
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σ1 receptor ligands control a switch between passive and active threat responses.
Authors: Rennekamp Et al.
Nat Chem Biol 2016;12:552
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Alpha-2 adrenergic stimulation triggers Achilles tenocyte hypercellularity: Comparison between two model systems.
Authors: Backman Et al.
Scand J Med Sci Sports 2013;23:687
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