BRL 50481
Chemical Name: N,N,2-Trimethyl-5-nitro-benzenesulfonamide
Purity: ≥99%
Biological Activity
BRL 50481 is a selective, substrate-competitive inhibitor of phosphodiesterase (PDE) 7 (Ki = 180 nM). Displays > 200-fold selectivity over PDE1B, PDE1C, PDE2, PDE3, PDE4A4 and PDE5.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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beta-Adrenergic cAMP signals are predominantly regulated by phosphodiesterase type 4 in cultured adult rat aortic smooth muscle cells.
Zhai K, Hubert F, Nicolas V, Ji G, Fischmeister R, Leblais V
PLoS ONE, 2012;7(10):e47826. -
Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a selective inhibitor of phosphodiesterase 7: in vitro studies in human monocytes, lung macrophages, and CD8+ T-lymphocytes.
Smith et al.
Mol.Pharmacol., 2004;66:1679
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Citations for BRL 50481
The citations listed below are publications that use Tocris products. Selected citations for BRL 50481 include:
3 Citations: Showing 1 - 3
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β-Adrenergic cAMP signals are predominantly regulated by phosphodiesterase type 4 in cultured adult rat aortic smooth muscle cells.
Authors: Zhai Et al.
PLoS One 2012;7:e47826
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Phosphodiesterase 7 inhibition preserves DArgic neurons in cellular and rodent models of Parkinson disease.
Authors: Morales-Garcia Et al.
J Biol Chem 2011;6:e17240
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Chronic lymphocytic leukemia and B and T cells differ in their response to cyclic nucleotide phosphodiesterase inhibitors.
Authors: Meyers Et al.
J Immunol 2009;182:5400
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