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Bromocriptine mesylate

Catalog #: 0427
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
0427/50
Bromocriptine mesylate | CAS No. 22260-51-1 | Non-selective Dopamine Receptor Agonists
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Description: D2-like agonist (D2>D3>D4)

Chemical Name: (5'a)-2-Bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)ergotaman-3',6',18-trione mesylate

Purity: ≥98%

Product Details
Citations (3)
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Biological Activity

Bromocriptine mesylate is a selective D3 and D2 dopamine receptor agonist (Ki values are ~ 5 nM and ~ 8 nM respectively). Activates both isoforms of D2 receptor (EC50 values are 0.10-0.12 nM and 4.4 nM for D2L and D2S receptors, respectively. Bromocriptine shows anti-Aβ effects that are increased in combination with Cromolyn (Cat. No. 6424) and Topiramate (Cat. No. 3620). Also lowers glucose and increases insulin sensitivity in vivo.

Technical Data

M.Wt:
750.7
Formula:
C32H40BrN5O5.CH3SO3H
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
22260-51-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  2. Bromocriptine produces decreases in cocaine self-administration in the rat.
    Aubner et al.
    Neuropsychopharmacology, 1990;3:101
  3. Bromocriptine in Parkinson disease.
    Lieberman and Goldstein
    Pharmacol.Rev., 1985;37:217
  4. DA receptor pharmacology.
    Seeman and Van Tol
    Trends Pharmacol.Sci., 1994;15:264
  5. The effects of chronic bromocri. treatment on behaviour and DA receptor binding in the rat striatum.
    Traub et al.
    Eur.J.Pharmacol., 1985;118:147

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Citations for Bromocriptine mesylate

The citations listed below are publications that use Tocris products. Selected citations for Bromocriptine mesylate include:

3 Citations: Showing 1 - 3

  1. A novel luminescence-based-β-arrestin recruitment assay for unmodified receptors.
    Authors: Pedersen Et al.
    J Biol Chem  2021;296:100503
  2. Identification and validation of the DA agonist bromocri. as a novel therapy for high-risk myelodysplastic syndromes and secondary acute myeloid leukemia.
    Authors: Liberante Et al.
    Oncotarget  2016;7:6609
  3. Age-dependent regulation of synaptic connections by DA D2 receptors.
    Authors: Jia Et al.
    Nat Neurosci  2013;16:1627

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