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BS 181 dihydrochloride

Catalog #: 5608 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5608/10
5608/50
BS 181 dihydrochloride | CAS No. 1883548-83-1 | Cyclin-dependent Kinase Inhibitors
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Description: Selective cdk7 inhibitor

Chemical Name: N5-(6-Aminohexyl)-3-(1-methylethyl)-N7-(phenylmethyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine dihydrochloride

Purity: ≥99%

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Biological Activity

BS 181 dihydrochloride is a selective cdk7 inhibitor (IC50 = 21 nM). Displays >40-fold selectivity for cdk7 over other cdks. Promotes cell cycle arrest and apoptosis in a range of cancer cells in vitro and inhibits MCF-7 tumor xenograft growth in mice.

Technical Data

M.Wt:
453.45
Formula:
C22H32N6.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
1883548-83-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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