BS 181 dihydrochloride

Key Product Details

Product Description

BS 181 dihydrochloride is a selective cdk7 inhibitor (IC₅₀ = 21 nM). Displays >40-fold selectivity for cdk7 over other cdks. Promotes cell cycle arrest and apoptosis in a range of cancer cells in vitro and inhibits MCF-7 tumor xenograft growth in mice.

Product Specifications for BS 181 dihydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for BS 181 dihydrochloride

The following data is based on the product molecular weight 453.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.21 mL	11.03 mL	22.05 mL
5 mM	0.44 mL	2.21 mL	4.41 mL
10 mM	0.22 mL	1.10 mL	2.21 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Ali The development of a selective cyclin-dependent kinase inhibitor that shows antitumor activity. Cancer Res. 2009 PMID: 19638587

Product Documents for BS 181 dihydrochloride