BTD
Chemical Name: 6-Methyl-N-[3-(tricyclo[3.3.1.13,7]dec-1-yloxy)propyl]-4H-1,2,4-benzothiadiazine-3-propanamide-1,1-dioxide
Purity: ≥98%
Biological Activity
BTD is a selective TRPC5 activator (EC50 = 1.4 μM in a calcium influx assay, 1.3 μM in whole cell patch clamp assay). Displays >14.5-fold selectivity for TRPC5 over other TRP channels (EC50 = 20.6 μM for TRPM8). Also activates TRPC1:5 and TRPC4:5 heteromers.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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A benzothiadiazine derivative and methylprednisolone are novel and selective activators of transient receptor potential canonical 5 (TRPC5) channels.
Beckmann et al.
Cell Calcium., 2017;66:10
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