C 75
Chemical Name: (2R*,3S*)-Tetrahydro-4-methylene-2-octyl-5-oxo-3-furancarboxylic acid
Purity: ≥95%
Biological Activity
C 75 is a synthetic inhibitor of fatty acid synthase (FASN); inhibits fatty acid synthesis in vitro and in vivo. Displays anorectic effects. Induces apoptosis in MCF-7 xenografts and exhibits antitumor activity.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells.
Zhou et al.
Cancer Res., 2003;63:7330 -
The anorexigenic fatty acid synthase inhibitor, C45, is a nonspecific neuronal activator.
Takahashi et al.
Endocrinology, 2004;145:184 -
Synthesis and antitumor activity of an inhibitor of fatty acid synthase.
Kuhajda et al.
Proc.Natl.Acad.Sci., 2000;97:3450 -
Chronic C75 treatment of diet-induced obese mice increases fat oxidation and reduces food intake to reduce adipose mass.
Thupari et al.
Am.J.Physiol.Endocrinol.Metab., 2004;287:97
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Citation for C 75
The citations listed below are publications that use Tocris products. Selected citations for C 75 include:
1 Citation: Showing 1 - 1
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The fatty acid synthase inhibitor triclosan: repurposing an anti-microbial agent for targeting prostate cancer.
Authors: Sadowski Et al.
Oncotarget 2014;5:9362
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