C 87
Chemical Name: 3-Phenyl-1-(4-phenyl-2-thiazolyl)-1H-pyrazole-4,5-dione 4-[2-(4-chloro-3-nitrophenyl)hydrazone]
Purity: ≥98%
Biological Activity
C 87 is a TNF-α inhibitor (Kd = 110 nM for hTNF-α). Inhibits TNF-α-induced cytotoxicity in L929 fibroblast cells. Attenuates inflammation and increases survival in a mouse hepatitis model.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Multifactorial Experimental Design to Optimize the Anti-Inflammatory and Proangiogenic Potential of Mesenchymal Stem Cell Spheroids
KC Murphy, J Whitehead, PC Falahee, D Zhou, SI Simon, JK Leach
Stem Cells, 2017;0(0):. -
A novel small-molecule tumor necrosis factor α inhibitor attenuates inflammation in a hepatitis mouse model.
Ma et al.
J.Biol.Chem., 2014;289:12457
Product Datasheets
Citations for C 87
The citations listed below are publications that use Tocris products. Selected citations for C 87 include:
2 Citations: Showing 1 - 2
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Overexpression of the C-domain of angiotensin-converting enzyme reduces melanoma growth by stimulating M1 macrophage polarization.
Authors: Markus Et al.
J Biol Chem 2019;294:4368-4380
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Microglia-Triggered Plasticity of Intrinsic Excitability Modulates Psychomotor Behaviors in Acute Cerebellar Inflammation.
Authors: Minsoo Et al.
Cell Rep 2019;28:2923-2938.e8
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