CaCCinh-A01
Chemical Name: 6-(1,1-Dimethylethyl)-2-[(2-furanylcarbonyl)amino]-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid
Purity: ≥99%
Biological Activity
CaCCinh-A01 is a calcium-activated chloride channel (CaCC) inhibitor (IC50 ~ 10 μM). Inhibits CaCC currents in human bronchial and intestinal cells. Also inhibits TMEM16A channels (IC50 = 2.1 μM, in TMEM16A-expressing FRT cells).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells.
Namkung et al.
J.Biol.Chem., 2011;286:2365 -
Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channel.
De La Fuente et al.
Mol.Pharmacol., 2008;73:758
Product Datasheets
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Citations for CaCCinh-A01
The citations listed below are publications that use Tocris products. Selected citations for CaCCinh-A01 include:
7 Citations: Showing 1 - 7
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Cell surface-bound La protein regulates the cell fusion stage of osteoclastogenesis.
Authors: Kamran Et al.
Nat Commun 2023;14:616
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The TMEM16A blockers benzbromarone and MONNA cause intracellular Ca2+-release in mouse bronchial smooth muscle cells
Authors: Dwivedi Et al.
Eur J Pharmacol 2023;
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Evidence for tetrodotoxin-resistant spontaneous myogenic contractions of mouse isolated stomach that are dependent on acetylcholine.
Authors: Armen Et al.
Br J Pharmacol 2022;179:1187-1200
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Estrogen receptor-α expressing neurons in the ventrolateral VMH regulate glucose balance.
Authors: Rui Et al.
Nat Commun 2020;11:2165
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The odorant receptor OR2W3 on airway smooth muscle evokes bronchodilation via a cooperative chemosensory tradeoff between TMEM16A and CFTR.
Authors: Richard C Et al.
Proc Natl Acad Sci U S A 2020;117:28485-28495
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Fusion Stage of HIV-1 Entry Depends on Virus-Induced Cell Surface Exposure of Phosphatidylserine.
Authors: Zaitseva Et al.
Cell Host Microbe 2017;22:99
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Conditional knockout of TMEM16A/anoctamin1 abolishes the calcium-activated chloride current in mouse vomeronasal sensory neurons.
Authors: Amjad Et al.
J Gen Physiol 2015;145:285
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