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Caffeic acid-pYEEIE

Catalog #: 1935
1 Citation Datasheet / COA / SDS

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Caffeic acid-pYEEIE
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Description: Phosphopeptide ligand for src SH2 domain

Chemical Name: N-[3-(3,4-Dihydroxyphenyl)-1-oxo-2-propenyl]-O-phosphono-L-tyrosyl-L-α-glutamyl-L-α-glutamyl-L-isoleucyl-L-glutamic acid

Purity: ≥95%

Product Details
Citations (1)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Caffeic acid-pYEEIE is a phosphopeptide ligand for the src SH2 domain (IC50 = 42 nM); displays 30-fold higher affinity than N-acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu (Ac-pYEEIE, Cat. No. 1927).

Technical Data

M.Wt:
923.82
Formula:
C39H50N5O19P
Sequence:
YEEIE

(Modifications: Tyr-1 = N-[3-(3,4-Dihydroxyphenyl)-1-oxo-2-propenyl]-)-pTyr)

Solubility:
Soluble to 2 mg/ml in PBS
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
507471-72-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Design and characterization of non-phosphopeptide inhibitors for src family SH2 domains.
    Park et al.
    Bioorg.Med.Chem.Lett., 2002;12:2711

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Citation for Caffeic acid-pYEEIE

The citations listed below are publications that use Tocris products. Selected citations for Caffeic acid-pYEEIE include:

1 Citation: Showing 1 - 1

  1. A selective NMR probe to monitor the conformational transition from inactive to active kinase.
    Authors: Xie Et al.
    J Neurosci  2015;10:262

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