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Calmidazolium chloride

Catalog #: 2561
3 Citations Datasheet / COA / SDS
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2561/10
Calmidazolium chloride | CAS No. 57265-65-3 | Calcium Binding Protein Modulator Antagonists
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Description: Calmodulin antagonist
Alternative Names: R 24571

Chemical Name: 1-[Bis(4-chlorophenyl)methyl]-3-[2-(2,4-dichlorophenyl)-2-(2,4-dichlorobenzyloxy)ethyl]-1H-imidazolium chloride

Purity: ≥95%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Calmidazolium chloride is a calmodulin antagonist. Inhibits calmodulin-dependent phosphodiesterase and Ca2+-transporting ATPase with IC50 values of 0.15 and 0.35 μM respectively. Also causes elevation of intracellular calcium in HL-60 cells, independent of calmodulin inhibition.

Technical Data

M.Wt:
687.7
Formula:
C31H23Cl7N2O
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥95%
Storage:
Store at +4°C
CAS No:
57265-65-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Calmidazolium chloride

The citations listed below are publications that use Tocris products. Selected citations for Calmidazolium chloride include:

3 Citations: Showing 1 - 3

  1. JIB-04, A Small Molecule Histone Demethylase Inhibitor, Selectively Targets Colorectal Cancer Stem Cells by Inhibiting the Wnt/β-Catenin Signaling Pathway.
    Authors: Kim Et al.
    Sci Rep  2018;8:6611
  2. Calmodulin enhances ribbon replenishment and shapes filtering of synaptic transmission by cone photoreceptors.
    Authors: Hook Et al.
    J Gen Physiol  2014;144:357
  3. Endoplasmic reticulum membrane reorganization is regulated by ionic homeostasis.
    Authors: Varadarajan Et al.
    PLoS One  2013;8:e56603

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