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(-)-Cannabidiol

Catalog #: 1570
5 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1570/10
1570/50
(-)-Cannabidiol | CAS No. 13956-29-1 | Non-selective Cannabinoid Receptor Antagonists
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Description: Natural cannabinoid; GPR55 antagonist, weak CB1 antagonist, CB2 inverse agonist and AMT inhibitor
Alternative Names: CBD

Chemical Name: 2-[(1R,6R)-3-Methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol

Purity: ≥99%

Product Details
Citations (5)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

(-)-Cannabidiol is a non-psychotropic constituent of cannabis that is anticonvulsive, antihyperalgesic and neuroprotective in vivo. GPR55 and weak CB1 antagonist (IC50 values are 0.445 and 3.35 μM), CB2 receptor inverse agonist and inhibitor of anandamide uptake (IC50 = 27.5 μM). Also inhibits FABPs and a weak agonist at TRP vanilloid receptors (EC50 = 3.5 μM). Reduces inflammation and LPS-induced cytokine production in cultured microglial cells.

Technical Data

M.Wt:
314.47
Formula:
C21H30O2
Solubility:
Soluble to 75 mM in ethanol and to 75 mM in DMSO
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
13956-29-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for (-)-Cannabidiol

The citations listed below are publications that use Tocris products. Selected citations for (-)-Cannabidiol include:

5 Citations: Showing 1 - 5

  1. Paraneoplastic cerebellar degeneration: Yo antibody alters mitochondrial calcium buffering capacity.
    Authors: Panja Et al.
    Neuropathol Appl Neurobiol  2019;45:141
  2. Cannabidiol enhances MOR antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor.
    Authors: Rodríguez-Muñoz Et al.
    Mol Brain  2018;11:51
  3. Cannabidiol reduces Aβ-induced neuroinflammation and promotes hippocampal neurogenesis through PPARγ involvement.
    Authors: Esposito Et al.
    Proc Natl Acad Sci U S A  2011;6:e28668
  4. Increasing antiproliferative properties of endocannabinoids in N1E-115 neuroblastoma cells through inhibition of their metabolism.
    Authors: Hamtiaux Et al.
    PLoS One  2011;6:e26823
  5. The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo.
    Authors: Whyte Et al.
    PLoS One  2009;106:16511

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