Caspase-3 Colorimetric Assay Kit
Caspase-3 Colorimetric Assay Kit Summary
Specifications
Product Datasheets
Background: Caspase-3
Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. They are expressed as latent zymogens and are activated by an autoproteolytic mechanism or by processing by other proteases (frequently other caspases). Human caspases can be subdivided into three functional groups: cytokine activation (caspase-1, -4, -5, and -13), apoptosis initiation (caspase-2, -8, -9, -and -10), and apoptosis execution (caspase-3, -6, and -7).
Caspases are regulated by a variety of stimili, including APAF1, CFLAR/FLIP, NOL3/ARC, and members of the inhibitor of apoptosis (IAP) family such as BIRC1/NAIP, BIRC2/cIAP-1, BIRC3/cIAP-2, BIRC4/XIAP, BIRC5/Survivin, and BIRC7/Livin. IAP activity is modulated by DIABLO/SMAC or PRSS25/HTRA2/Omi. Cell-permeable and irreversible peptide inhibitors are also available for different caspases.
Citations for Caspase-3 Colorimetric Assay Kit
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 10
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Azadirachtin Attenuates Lipopolysaccharide-Induced ROS Production, DNA Damage, and Apoptosis by Regulating JNK/Akt and AMPK/mTOR-Dependent Pathways in Rin-5F Pancreatic Beta Cells
Authors: A John, H Raza
Biomedicines, 2021-12-18;9(12):. 2021-12-18
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Apigenin Induces Autophagy and Cell Death by Targeting EZH2 under Hypoxia Conditions in Gastric Cancer Cells
Authors: TW Kim, HG Lee
International Journal of Molecular Sciences, 2021-12-15;22(24):. 2021-12-15
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Xeno-free workflow exhibits comparable efficiency and quality of keratinocytes isolated from human skin biopsies
Authors: C Lagerwall, H Shahin, S Abdallah, I Steinvall, M Elmasry, F Sjöberg, AT El-Serafi
Regenerative Therapy, 2021-09-29;18(0):401-407. 2021-09-29
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NPAS4 suppresses propofol-induced neurotoxicity by inhibiting autophagy in hippocampal neuronal cells
Authors: T Zhang, D Ji, J Sun, J Song, L Nie, N Sun
Archives of biochemistry and biophysics, 2021-08-18;711(0):109018. 2021-08-18
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Physiological responses (Hsps 60 and 32, caspase 3, H2O2 scavenging, and photosynthetic activity) of the coral Pocillopora damicornis under thermal and high nitrate stresses
Authors: M Thummasan, BE Casareto, C Ramphul, T Suzuki, K Toyoda, Y Suzuki
Marine pollution bulletin, 2021-07-20;171(0):112737. 2021-07-20
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Surfactin exerts an anti-cancer effect through inducing allergic reactions in melanoma skin cancer
Authors: HY Kim, H Jung, HM Kim, HJ Jeong
International immunopharmacology, 2021-07-04;99(0):107934. 2021-07-04
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Nitrofurazone repurposing towards design and synthesis of novel apoptotic-dependent anticancer and antimicrobial agents: Biological evaluation, kinetic studies and molecular modeling
Authors: MH El-Wakil, MA Meheissen, MM Abu-Serie
Bioorganic chemistry, 2021-05-07;113(0):104971. 2021-05-07
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8-Alkylmercaptocaffeine derivatives: antioxidant, molecular docking, and in-vitro cytotoxicity studies
Authors: S Sargazi, S Shahraki, O Shahraki, F Zargari, R Sheervalil, S Maghsoudi, MN Soltani Ra, R Saravani
Bioorganic chemistry, 2021-04-09;111(0):104900. 2021-04-09
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Effects of Bovine Colostrum with or without Egg on In Vitro Bacterial-Induced Intestinal Damage with Relevance for SIBO and Infectious Diarrhea
Authors: RJ Playford, N Choudhry, P Kelly, T Marchbank
Nutrients, 2021-03-22;13(3):. 2021-03-22
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Apoptotic Effects of Anthocyanins from Vitis coignetiae Pulliat Are Enhanced by Augmented Enhancer of the Rudimentary Homolog (ERH) in Human Gastric Carcinoma MKN28 Cells
Authors: C Park, WS Lee, SI Go, SH Jeong, J Yoo, HJ Cha, YJ Lee, HS Kim, SH Leem, HJ Kim, GS Kim, SC Hong, YH Choi
International Journal of Molecular Sciences, 2021-03-16;22(6):. 2021-03-16
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Precisely Fabricated Sulpiride-Loaded Nanolipospheres with Ameliorated Oral Bioavailability and Antidepressant Activity
Authors: SM Mohyeldin, WM Samy, D Ragab, DA Abdelmonsi, RG Aly, NA Elgindy
International Journal of Nanomedicine, 2021-03-09;16(0):2013-2044. 2021-03-09
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Critical implication of the PTEN/PI3K/AKT pathway during BMP2-induced heterotopic ossification
Authors: J Dong, X Xu, Q Zhang, Z Yuan, B Tan
Molecular Medicine Reports, 2021-02-04;23(4):. 2021-02-04
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Activated ROCK/Akt/eNOS and ET-1/ERK pathways in 5-fluorouracil-induced cardiotoxicity: modulation by simvastatin
Authors: RN Muhammad, N Sallam, HS El-Abhar
Sci Rep, 2020-09-07;10(1):14693. 2020-09-07
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Hemistepsin A protects human keratinocytes against hydrogen peroxide-induced oxidative stress through activation of the Nrf2/HO-1 signaling pathway
Authors: C Park, H Lee, JS Noh, CY Jin, GY Kim, JW Hyun, SH Leem, YH Choi
Arch. Biochem. Biophys., 2020-07-24;691(0):108512. 2020-07-24
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Sensitivity of allyl isothiocyanate to induce apoptosis via ER stress and the mitochondrial pathway upon ROS production in colorectal adenocarcinoma cells
Authors: JH Chiang, FJ Tsai, YM Hsu, MC Yin, HY Chiu, JS Yang
Oncol. Rep., 2020-07-21;0(0):. 2020-07-21
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Potential effects of allyl isothiocyanate on inhibiting cellular proliferation and inducing apoptotic pathway in human cisplatin-resistant oral cancer cells
Authors: PY Chang, FJ Tsai, DT Bau, YM Hsu, JS Yang, MG Tu, SL Chiang
J. Formos. Med. Assoc., 2020-07-03;0(0):. 2020-07-03
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Nicotine encourages oxidative stress and impairment of rats' brain mitigated by Spirulina platensis lipopolysaccharides and low-dose ionizing radiation
Authors: SM Elsonbaty, AFM Ismail
Arch. Biochem. Biophys., 2020-04-25;0(0):108382. 2020-04-25
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Hydrophobicity-Tuned Periodic Mesoporous Organo-Silica Nanoparticles for Photodynamic Therapy
Authors: CH Lin, R Kumar Kank, P Busa, CH Lee
Int J Mol Sci, 2020-04-08;21(7):. 2020-04-08
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New insights in acetaminophen toxicity: HMGB1 contributes by itself to amplify hepatocyte necrosis in vitro through the TLR4-TRIF-RIPK3 axis
Authors: C Minsart, C Liefferinc, A Lemmers, C Dressen, E Quertinmon, I Leclercq, J Devière, R Moreau, T Gustot
Sci Rep, 2020-03-27;10(1):5557. 2020-03-27
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The Effects of Inhibition of MicroRNA-375 in a Mouse Model of Doxorubicin-Induced Cardiac Toxicity
Authors: H Zhang, Y Tian, D Liang, Q Fu, L Jia, D Wu, X Zhu
Med. Sci. Monit., 2020-03-18;26(0):e920557. 2020-03-18
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MicroRNA-143 Increases Oxidative Stress and Myocardial Cell Apoptosis in a Mouse Model of Doxorubicin-Induced Cardiac Toxicity
Authors: XQ Li, YK Liu, J Yi, JS Dong, PP Zhang, L Wan, K Li
Med. Sci. Monit., 2020-03-14;26(0):e920394. 2020-03-14
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l-Theanine improves functional recovery after traumatic spinal cord injury in rats
Authors: CC Yang, KC Chang, MH Wang, HC Tseng, HS Soung, CH Fang, YW Lin, KY Li, CC Tsai
J. Formos. Med. Assoc., 2019-12-05;0(0):. 2019-12-05
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Pan-caspase inhibitor F573 mitigates liver ischemia reperfusion injury in a murine model
Authors: M Bral, R Pawlick, B Marfil-Gar, N Dadheech, J Hefler, A Thiesen, AMJ Shapiro
PLoS ONE, 2019-11-26;14(11):e0224567. 2019-11-26
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Iron Overload Damages the Endothelial Mitochondria via the ROS/ADMA/DDAHII/eNOS/NO Pathway
Authors: H He, Y Qiao, Q Zhou, Z Wang, X Chen, D Liu, D Yin, M He
Oxid Med Cell Longev, 2019-11-12;2019(0):2340392. 2019-11-12
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Isorhamnetin Induces Cell Cycle Arrest and Apoptosis Via Reactive Oxygen Species-Mediated AMP-Activated Protein Kinase Signaling Pathway Activation in Human Bladder Cancer Cells
Authors: C Park, HJ Cha, EO Choi, H Lee, H Hwang-Bo, SY Ji, MY Kim, SY Kim, SH Hong, J Cheong, GY Kim, SJ Yun, HJ Hwang, WJ Kim, YH Choi
Cancers (Basel), 2019-10-04;11(10):. 2019-10-04
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A comparative study: the prospective influence of nanovectors in leveraging the chemopreventive potential of COX-2 inhibitors against skin cancer
Authors: NK Abo Aasy, D Ragab, MA Sallam, DA Abdelmonsi, RG Aly, KA Elkhodairy
Int J Nanomedicine, 2019-09-17;14(0):7561-7581. 2019-09-17
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High Concentration of C5a-Induced Mitochondria-Dependent Apoptosis in Murine Kidney Endothelial Cells
Authors: IJ Tsai, WC Lin, YH Yang, YL Tseng, YH Lin, CH Chou, YK Tsau
Int J Mol Sci, 2019-09-10;20(18):. 2019-09-10
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CRM197 reverses paclitaxel resistance by inhibiting the NAC-1/Gadd45 pathway in paclitaxel-resistant ovarian cancer cells
Authors: XH Tang, H Li, XS Zheng, MS Lu, Y An, XL Zhang
Cancer Med, 2019-09-06;0(0):. 2019-09-06
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Derrone induces autophagic cell death through induction of ROS and ERK in A549 cells
Authors: MJ Kang, SY Kim, EB Kwon, YH Jo, MK Lee, HS Lee, DO Moon, MO Kim
PLoS ONE, 2019-06-19;14(6):e0218659. 2019-06-19
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Influence of salinity on spermatogenesis in adult Nile tilapia (Oreochromis niloticus) testis
Authors: AB Cruz Vieir, AA Weber, YM Ribeiro, RK Luz, N Bazzoli, E Rizzo
Theriogenology, 2019-03-21;131(0):1-8. 2019-03-21
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Dexmedetomidine Attenuates Lung Injury by Promoting Mitochondrial Fission and Oxygen Consumption
Authors: JR Zhang, Q Lin, FQ Liang, T Xie
Med. Sci. Monit., 2019-03-11;25(0):1848-1856. 2019-03-11
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Structural characterization and in vitro antitumor activity of A polysaccharide from Artemisia annua L. (Huang Huahao)
Authors: L Yan, C Xiong, P Xu, J Zhu, Z Yang, H Ren, Q Luo
Carbohydr Polym, 2019-02-25;213(0):361-369. 2019-02-25
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Synergistic study of a Danshen (Salvia Miltiorrhizae Radix et Rhizoma) and Sanqi (Notoginseng Radix et Rhizoma) combination on cell survival in EA.hy926 cells
Authors: X Zhou, V Razmovski-, A Kam, D Chang, CG Li, K Chan, A Bensoussan
BMC Complement Altern Med, 2019-02-21;19(1):50. 2019-02-21
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Efficient biofunctionalization of MoS2 nanosheets with peptides as intracellular fluorescent biosensor for sensitive detection of caspase-3 activity
Authors: X Li, Y Li, Q Qiu, Q Wen, Q Zhang, W Yang, L Yuwen, L Weng, L Wang
J Colloid Interface Sci, 2019-02-04;543(0):96-105. 2019-02-04
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Cilostazol protects hepatocytes against alcohol-induced apoptosis via activation of AMPK pathway
Authors: YJ Lee, MS Shu, JY Kim, YH Kim, KH Sim, WJ Sung, JR Eun
PLoS ONE, 2019-01-29;14(1):e0211415. 2019-01-29
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The effects and mechanism of peiminine-induced apoptosis in human hepatocellular carcinoma HepG2 cells
Authors: X Chao, G Wang, Y Tang, C Dong, H Li, B Wang, J Wu, J Zhao
PLoS ONE, 2019-01-07;14(1):e0201864. 2019-01-07
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Camalexin Induces Apoptosis via the ROS-ER Stress-Mitochondrial Apoptosis Pathway in AML Cells
Authors: Y Yang, G Wang, W Wu, S Yao, X Han, D He, J He, G Zheng, Y Zhao, Z Cai, R Yu
Oxid Med Cell Longev, 2018-11-14;2018(0):7426950. 2018-11-14
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Manilkara zapota (L.) P. Royen Leaf Water Extract Induces Apoptosis in Human Hepatocellular Carcinoma (HepG2) Cells via ERK1/2/Akt1/JNK1 Signaling Pathways
Authors: BL Tan, ME Norhaizan, LC Chan
Evid Based Complement Alternat Med, 2018-11-05;2018(0):7826576. 2018-11-05
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Design, synthesis, biological evaluation and dynamics simulation of indazole derivatives with antiangiogenic and antiproliferative anticancer activity
Authors: NMY Elsayed, RAT Serya, MF Tolba, M Ahmed, K Barakat, DA Abou El El, KAM Abouzid
Bioorg. Chem., 2018-11-02;82(0):340-359. 2018-11-02
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Collagen regulates the ability of endothelial progenitor cells to protect hypoxic myocardium through a mechanism involving miR-377/VE-PTP axis
Authors: AM Rosca, DN Mitroi, V Cismasiu, R Badea, G Necula-Pet, MB Preda, C Niculite, R Tutuianu, S Szedlacsek, A Burlacu
J. Cell. Mol. Med., 2018-07-25;0(0):. 2018-07-25
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Camel Milk Ameliorates 5-Fluorouracil-Induced Renal Injury in Rats: Targeting MAPKs, NF-?B and PI3K/Akt/eNOS Pathways
Authors: HH Arab, SA Salama, IA Maghrabi
Cell. Physiol. Biochem., 2018-04-20;46(4):1628-1642. 2018-04-20
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LncRNA TP73-AS1 predicts the prognosis of bladder cancer patients and functions as a suppressor for bladder cancer by EMT pathway
Authors: Z Tuo, J Zhang, W Xue
Biochem. Biophys. Res. Commun., 2018-04-11;0(0):. 2018-04-11
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Reactive oxygen species-dependent apoptosis induction by water extract ofCitrus unshiupeel in MDA-MB-231 human breast carcinoma cells
Authors: MY Kim, EO Choi, H HwangBo, DH Kwon, KI Ahn, HJ Kim, SY Ji, SH Hong, JW Jeong, GY Kim, C Park, YH Choi
Nutr Res Pract, 2018-03-21;12(2):129-134. 2018-03-21
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Effects of glabridin combined with 5-fluorouracil on the proliferation and apoptosis of gastric cancer cells
Authors: L Zhang, H Chen, M Wang, X Song, F Ding, J Zhu, X Li
Oncol Lett, 2018-03-14;15(5):7037-7045. 2018-03-14
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LncRNA SNHG16 Functions as an Oncogene by Sponging MiR-4518 and Up-Regulating PRMT5 Expression in Glioma
Authors: YF Lu, XL Cai, ZZ Li, J Lv, YA Xiang, JJ Chen, WJ Chen, WY Sun, XM Liu, JB Chen
Cell. Physiol. Biochem., 2018-03-06;45(5):1975-1985. 2018-03-06
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Staphylococcus aureus triggers a shift from influenza virus-induced apoptosis to necrotic cell death
Authors: A van Krücht, JJ Wilden, S Niemann, G Peters, B Löffler, S Ludwig, C Ehrhardt
FASEB J., 2018-01-11;0(0):fj201701006R. 2018-01-11
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Piceatannol-Induced Apoptosis Is Reversed by N-Acetyl-L-cysteine through Restoration of XIAP Expression
Authors: CY Jin, IMN Molagoda, C Park, TK Kwon, SJ Yun, WJ Kim, GY Kim, YH Choi
Biol. Pharm. Bull., 2018-01-01;41(9):1372-1378. 2018-01-01
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Epigallocatechin-3-gallate counters cisplatin toxicity of rat testes
Authors: AA Fouad, HO Qutub, AEA Fouad, AM Audeh, WN Al-Melhim
Pharm Biol, 2017-12-01;55(1):1710-1714. 2017-12-01
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Efficiency of newly formulated camptothecin with ?-cyclodextrin-EDTA-Fe3O4 nanoparticle-conjugated nanocarriers as an anti-colon cancer (HT29) drug
Authors: P Krishnan, M Rajan, S Kumari, S Sakinah, SP Priya, F Amira, L Danjuma, M Pooi Ling, S Fakurazi, P Arulselvan, A Higuchi, R Arumugam, AA Alarfaj, MA Munusamy, RA Hamat, G Benelli, K Murugan, SS Kumar
Sci Rep, 2017-09-08;7(1):10962. 2017-09-08
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Pterostilbene exerts anticancer activity on non-small-cell lung cancer via activating endoplasmic reticulum stress
Authors: Z Ma, Y Yang, S Di, X Feng, D Liu, S Jiang, W Hu, Z Qin, Y Li, J Lv, C Fan, X Yan, X Li
Sci Rep, 2017-08-14;7(1):8091. 2017-08-14
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Elucidation of Molecular Mechanisms of Streptozotocin-Induced Oxidative Stress, Apoptosis, and Mitochondrial Dysfunction in Rin-5F Pancreatic ?-Cells
Authors: AMTA Nahdi, A John, H Raza
Oxid Med Cell Longev, 2017-08-06;2017(0):7054272. 2017-08-06
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Cudraflavone C Induces Apoptosis of A375.S2 Melanoma Cells through Mitochondrial ROS Production and MAPK Activation
Authors: CW Lee, FL Yen, HH Ko, SY Li, YC Chiang, MH Lee, MH Tsai, LF Hsu
Int J Mol Sci, 2017-07-13;18(7):. 2017-07-13
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Bufalin sensitizes human bladder carcinoma cells to TRAIL-mediated apoptosis
Authors: KH Kang, MH Han, JW Jeong, C Park, SH Lee, HW Lee, SH Hong, YH Choi, SH Hong
Oncol Lett, 2017-05-22;14(1):853-859. 2017-05-22
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Inhibition of Autophagy Promotes Salinomycin-Induced Apoptosis via Reactive Oxygen Species-Mediated PI3K/AKT/mTOR and ERK/p38 MAPK-Dependent Signaling in Human Prostate Cancer Cells
Authors: KY Kim, KI Park, SH Kim, SN Yu, SG Park, YW Kim, YK Seo, JY Ma, SC Ahn
Int J Mol Sci, 2017-05-18;18(5):. 2017-05-18
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Long non-coding RNA MALAT1 contributes to cell apoptosis by sponging miR-124 in Parkinson disease
Authors: W Liu, Q Zhang, J Zhang, W Pan, J Zhao, Y Xu
Cell Biosci, 2017-04-21;7(0):19. 2017-04-21
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Endogenous Two-Photon Excited Fluorescence Imaging Characterizes Neuron and Astrocyte Metabolic Responses to Manganese Toxicity
Authors: E Stuntz, Y Gong, D Sood, V Liaudanska, D Pouli, KP Quinn, C Alonzo, Z Liu, DL Kaplan, I Georgakoud
Sci Rep, 2017-04-21;7(1):1041. 2017-04-21
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Suberoylanilide hydroxamic acid increases anti-cancer effect of tumor necrosis factor-? through up-regulation of TNF receptor 1 in lung cancer cells.
Authors: Bo Ra You, Bo Ram Han, Woo Hyun Park
Oncotarget, 2017-03-14;0(0):1949-2553. 2017-03-14
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Disrupting the blood-brain barrier by focused ultrasound induces sterile inflammation
Proc. Natl. Acad. Sci. U.S.A, 2016-12-19;0(0):. 2016-12-19
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Induction of apoptosis by ethanol extract of Evodia rutaecarpa in HeLa human cervical cancer cells via activation of AMP-activated protein kinase
Authors: Seon Young Park
Biosci Trends, 2016-11-27;0(0):. 2016-11-27
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Hydrogen Peroxide-Responsive Nanoparticle Reduces Myocardial Ischemia/Reperfusion Injury
J Am Heart Assoc, 2016-11-14;5(11):. 2016-11-14
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Upregulation of retinoic acid receptor-? reverses drug resistance in cholangiocarcinoma cells by enhancing susceptibility to apoptosis
Mol Med Rep, 2016-09-02;14(4):3602-8. 2016-09-02
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Bacteroides fragilis Enterotoxin Upregulates Heme Oxygenase-1 in Intestinal Epithelial Cells via a Mitogen-Activated Protein Kinases- and NF-?B-Dependent Pathway, Leading to Modulation of Apoptosis
Authors: Su Hyuk Ko
Infect Immun, 2016-08-19;0(0):. 2016-08-19
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Euphorbia factor L2 induces apoptosis in A549 cells through the mitochondrial pathway
Authors: M Lin, S Tang, C Zhang, H Chen, W Huang, Y Liu, J Zhang
Acta Pharm Sin B, 2016-07-30;7(1):59-64. 2016-07-30
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The mitochondrial ubiquitin ligase plays an anti-apoptotic role in cardiomyocytes by regulating mitochondrial fission
J Cell Mol Med, 2016-07-22;0(0):. 2016-07-22
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Anti-Cancer Effect of Lambertianic Acid by Inhibiting the AR in LNCaP Cells
Int J Mol Sci, 2016-07-07;17(7):. 2016-07-07
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Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics
Elife, 2016-05-23;5(0):. 2016-05-23
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Pulchrin A, a New Natural Coumarin Derivative of Enicosanthellum pulchrum, Induces Apoptosis in Ovarian Cancer Cells via Intrinsic Pathway
PLoS ONE, 2016-05-02;11(5):e0154023. 2016-05-02
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Diosmin protects against ethanol-induced gastric injury in rats: novel anti-ulcer actions.
Authors: Arab H, Salama S, Omar H, Arafa E, Maghrabi I
PLoS ONE, 2015-03-30;10(3):e0122417. 2015-03-30
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Erythropoietin protects cardiomyocytes from cell death during hypoxia/reperfusion injury through activation of survival signaling pathways.
Authors: Parvin A, Pranap R, Shalini U, Devendran A, Baker J, Dhanasekaran A
PLoS ONE, 2014-09-19;9(9):e107453. 2014-09-19
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Augmented efficacy with the combination of blockade of the Notch-1 pathway, bortezomib and romidepsin in a murine MT-1 adult T-cell leukemia model.
Authors: Yu P, Petrus M, Ju W, Zhang M, Conlon K, Nakagawa M, Maeda M, Bamford R, Waldmann T
Leukemia, 2014-08-14;29(3):556-66. 2014-08-14
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Protective effect of Aframomum melegueta phenolics against CCl(4)-induced rat hepatocytes damage; role of apoptosis and pro-inflammatory cytokines inhibition.
Authors: El-Halawany A, El Dine R, El Sayed N, Hattori M
Sci Rep, 2014-07-30;4(0):5880. 2014-07-30
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Telmisartan attenuates colon inflammation, oxidative perturbations and apoptosis in a rat model of experimental inflammatory bowel disease.
Authors: Arab H, Al-Shorbagy M, Abdallah D, Nassar N
PLoS ONE, 2014-05-15;9(5):e97193. 2014-05-15
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Adverse signaling of scavenger receptor class B1 and PGC1s in alcoholic hepatosteatosis and steatohepatitis and protection by betaine in rat.
Authors: Varatharajalu R, Garige M, Leckey L, Arellanes-Robledo J, Reyes-Gordillo K, Shah R, Lakshman M
Am J Pathol, 2014-05-06;184(7):2035-44. 2014-05-06
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Suberoylanilide hydroxamic acid-induced HeLa cell death is closely correlated with oxidative stress and thioredoxin 1 levels.
Authors: You B, Park W
Int J Oncol, 2014-03-12;44(5):1745-55. 2014-03-12
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Enhancement of TWIK-related acid-sensitive potassium channel 3 (TASK3) two-pore domain potassium channel activity by tumor necrosis factor alpha.
Authors: El Hachmane M, Rees K, Veale E, Sumbayev V, Mathie A
J Biol Chem, 2013-12-04;289(3):1388-401. 2013-12-04
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Curcumin-loaded nanoparticles enhance apoptotic cell death of U2OS human osteosarcoma cells through the Akt-Bad signaling pathway.
Authors: Peng S, Lee C, Hour M, Tsai S, Kuo D, Chen F, Shieh P, Yang J
Int J Oncol, 2013-11-14;44(1):238-46. 2013-11-14
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Upregulation of miR-18a-5p contributes to epidermal necrolysis in severe drug eruptions.
Authors: Ichihara A, Wang Z, Jinnin M, Izuno Y, Shimozono N, Yamane K, Fujisawa A, Moriya C, Fukushima S, Inoue Y, Ihn H
J Allergy Clin Immunol, 2013-11-01;133(4):1065-74. 2013-11-01
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Soy soluble polysaccharide induces apoptosis in HCT116 human colon cancer cells via reactive oxygen species generation.
Authors: Ko Y, Jeong J, Choi Y, Ryu C
Mol Med Rep, 2013-10-14;8(6):1767-72. 2013-10-14
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Valproic acid inhibits the growth of HeLa cervical cancer cells via caspase-dependent apoptosis.
Authors: Han B, You B, Park W
Oncol Rep, 2013-09-20;30(6):2999-3005. 2013-09-20
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Macrophages mediate gemcitabine resistance of pancreatic adenocarcinoma by upregulating cytidine deaminase.
Authors: Weizman, N, Krelin, Y, Shabtay-Orbach, A, Amit, M, Binenbaum, Y, Wong, R J, Gil, Z
Oncogene, 2013-09-02;33(29):3812-9. 2013-09-02
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Malignant melanoma cells acquire resistance to DNA interstrand cross-linking chemotherapeutics by p53-triggered upregulation of DDB2/XPC-mediated DNA repair.
Authors: Barckhausen C, Roos W, Naumann S, Kaina B
Oncogene, 2013-04-22;33(15):1964-74. 2013-04-22
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Suppression of neuroinflammatory and apoptotic signaling cascade by curcumin alone and in combination with piperine in rat model of olfactory bulbectomy induced depression.
Authors: Rinwa P, Kumar A, Garg S
PLoS ONE, 2013-04-17;8(4):e61052. 2013-04-17
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The ameliorative effects of L-2-oxothiazolidine-4-carboxylate on acetaminophen-induced hepatotoxicity in mice.
Authors: Choi, Jiwon, Park, Kwang-Hy, Kim, Sung Zoo, Shin, Jun Ho, Jang, Seon-Il
Molecules, 2013-03-18;18(3):3467-78. 2013-03-18
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The novel carboxamide analog ITR-284 induces caspase-dependent apoptotic cell death in human hepatocellular and colorectal cancer cells.
Authors: Liao Y, Lu C, Lai K, Yang J, Kuo S, Wen Y, Fushiya S, Wu T
Mol Med Rep, 2013-03-05;7(5):1539-44. 2013-03-05
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Combination of albendazole and 2-methoxyestradiol significantly improves the survival of HCT-116 tumor-bearing nude mice.
Authors: Ehteda, Anahid, Galettis, Peter, Pillai, Krishna, Morris, David L
BMC Cancer, 2013-02-23;13(0):86. 2013-02-23
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The critical role of mast cell-derived hypoxia-inducible factor-1alpha in human and mice melanoma growth.
Authors: Jeong H, Oh H, Nam S, Han N, Kim Y, Kim J, Lee S, Kim M, Moon P, Kim H, Oh H
Int J Cancer, 2012-12-03;132(11):2492-501. 2012-12-03
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Implications of altered glutathione metabolism in aspirin-induced oxidative stress and mitochondrial dysfunction in HepG2 cells.
Authors: Raza H, John A
PLoS ONE, 2012-04-30;7(4):e36325. 2012-04-30
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Citrus aurantium L. exhibits apoptotic effects on U937 human leukemia cells partly through inhibition of Akt.
Authors: Han MH, Lee WS, Lu JN
Int. J. Oncol., 2012-02-01;40(6):2090-6. 2012-02-01
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Proteasome inhibitors prevent caspase-1-mediated disease in rodents challenged with anthrax lethal toxin.
Authors: Muehlbauer SM, Lima H, Goldman DL, Jacobson LS, Rivera J, Goldberg MF, Palladino MA, Casadevall A, Brojatsch J
Am. J. Pathol., 2010-07-01;177(2):735-43. 2010-07-01
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Effective treatment of a murine model of adult T-cell leukemia using depsipeptide and its combination with unmodified daclizumab directed toward CD25.
Authors: Chen J, Zhang M, Ju W, Waldmann TA
Blood, 2008-10-23;113(6):1287-93. 2008-10-23
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Calu-3 human lung cancer cells and A-431 human epidermoid carcinoma cancer cells were treated with Staurosporine (5 μM) for 4 hours or DMSO to induce apoptosis. The cells were then collected, lysed and 150 μg of protein was used to measure Caspase-3 activity at 400 nm, following the instructions of the Caspase-3 Colorimetric Assay Kit (K106-100).