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Caspase-8 Colorimetric Assay Kit

Catalog #: K113-100
38 Citations Datasheet / COA / SDS

Discontinued Product

K113-100 has been discontinued.
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Citations (38)
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Caspase-8 Colorimetric Assay Kit Summary

Specifications

Source
N/A
Shipping Conditions
The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Species
Multi-Species

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Background: Caspase-8

Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. They are expressed as latent zymogens and are activated by an autoproteolytic mechanism or by processing by other proteases (frequently other caspases). Human caspases can be subdivided into three functional groups: cytokine activation (caspase-1, -4, -5, and -13), apoptosis initiation (caspase-2, -8, -9, -and -10), and apoptosis execution (caspase-3, -6, and -7).

Caspases are regulated by a variety of stimili, including APAF1, CFLAR/FLIP, NOL3/ARC, and members of the inhibitor of apoptosis (IAP) family such as BIRC1/NAIP, BIRC2/cIAP-1, BIRC3/cIAP-2, BIRC4/XIAP, BIRC5/Survivin, and BIRC7/Livin. IAP activity is modulated by DIABLO/SMAC or PRSS25/HTRA2/Omi. Cell-permeable and irreversible peptide inhibitors are also available for different caspases.

Entrez Gene IDs
841 (Human); 12370 (Mouse)
Alternate Names
AIS; androgen receptor; CASP8; Caspase8; Caspase-8; DHTRTFM; Dihydrotestosterone receptorHYSP1; HUMARA; Mch5; NR3C4KD; Nuclear receptor subfamily 3 group C member 4; SMAX1SBMA; spinal and bulbar muscular atrophy

Citations for Caspase-8 Colorimetric Assay Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

38 Citations: Showing 1 - 10
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  1. CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity
    Authors: J Joung, PC Kirchgatte, A Singh, JH Cho, SP Nety, RC Larson, RK Macrae, R Deasy, YY Tseng, MV Maus, F Zhang
    Nature Communications, 2022-03-25;13(1):1606.  2022-03-25
  2. Azadirachtin Attenuates Lipopolysaccharide-Induced ROS Production, DNA Damage, and Apoptosis by Regulating JNK/Akt and AMPK/mTOR-Dependent Pathways in Rin-5F Pancreatic Beta Cells
    Authors: A John, H Raza
    Biomedicines, 2021-12-18;9(12):.  2021-12-18
  3. Aprepitant Promotes Caspase-Dependent Apoptotic Cell Death and G2/M Arrest through PI3K/Akt/NF-kappaB Axis in Cancer Stem-Like Esophageal Squamous Cell Carcinoma Spheres
    Authors: H Javid, AR Afshari, F Zahedi Avv, J Asadi, SI Hashemy
    BioMed Research International, 2021-12-09;2021(0):8808214.  2021-12-09
  4. Apoptotic Effects of Anthocyanins from Vitis coignetiae Pulliat Are Enhanced by Augmented Enhancer of the Rudimentary Homolog (ERH) in Human Gastric Carcinoma MKN28 Cells
    Authors: C Park, WS Lee, SI Go, SH Jeong, J Yoo, HJ Cha, YJ Lee, HS Kim, SH Leem, HJ Kim, GS Kim, SC Hong, YH Choi
    International Journal of Molecular Sciences, 2021-03-16;22(6):.  2021-03-16
  5. Evaluation of the Impact of Cisplatin on Variances in the Expression Pattern of Leptin-Related Genes in Endometrial Cancer Cells
    Authors: D D?bru?, R Kie?basi?s, BO Grabarek, D Boro?
    Int J Mol Sci, 2020-06-10;21(11):.  2020-06-10
  6. Isorhamnetin Induces Cell Cycle Arrest and Apoptosis Via Reactive Oxygen Species-Mediated AMP-Activated Protein Kinase Signaling Pathway Activation in Human Bladder Cancer Cells
    Authors: C Park, HJ Cha, EO Choi, H Lee, H Hwang-Bo, SY Ji, MY Kim, SY Kim, SH Hong, J Cheong, GY Kim, SJ Yun, HJ Hwang, WJ Kim, YH Choi
    Cancers (Basel), 2019-10-04;11(10):.  2019-10-04
  7. Derrone induces autophagic cell death through induction of ROS and ERK in A549 cells
    Authors: MJ Kang, SY Kim, EB Kwon, YH Jo, MK Lee, HS Lee, DO Moon, MO Kim
    PLoS ONE, 2019-06-19;14(6):e0218659.  2019-06-19
  8. Dexmedetomidine Attenuates Lung Injury by Promoting Mitochondrial Fission and Oxygen Consumption
    Authors: JR Zhang, Q Lin, FQ Liang, T Xie
    Med. Sci. Monit., 2019-03-11;25(0):1848-1856.  2019-03-11
  9. Structural characterization and in vitro antitumor activity of A polysaccharide from Artemisia annua L. (Huang Huahao)
    Authors: L Yan, C Xiong, P Xu, J Zhu, Z Yang, H Ren, Q Luo
    Carbohydr Polym, 2019-02-25;213(0):361-369.  2019-02-25
  10. Manilkara zapota (L.) P. Royen Leaf Water Extract Induces Apoptosis in Human Hepatocellular Carcinoma (HepG2) Cells via ERK1/2/Akt1/JNK1 Signaling Pathways
    Authors: BL Tan, ME Norhaizan, LC Chan
    Evid Based Complement Alternat Med, 2018-11-05;2018(0):7826576.  2018-11-05
  11. Sildenafil protects neuronal cells from mitochondrial toxicity induced by β-amyloid peptide via ATP-sensitive K+ channels
    Authors: Y Son, K Kim, HR Cho
    Biochem. Biophys. Res. Commun., 2018-04-21;500(2):504-510.  2018-04-21
  12. Reactive oxygen species-dependent apoptosis induction by water extract ofCitrus unshiupeel in MDA-MB-231 human breast carcinoma cells
    Authors: MY Kim, EO Choi, H HwangBo, DH Kwon, KI Ahn, HJ Kim, SY Ji, SH Hong, JW Jeong, GY Kim, C Park, YH Choi
    Nutr Res Pract, 2018-03-21;12(2):129-134.  2018-03-21
  13. Effects of glabridin combined with 5-fluorouracil on the proliferation and apoptosis of gastric cancer cells
    Authors: L Zhang, H Chen, M Wang, X Song, F Ding, J Zhu, X Li
    Oncol Lett, 2018-03-14;15(5):7037-7045.  2018-03-14
  14. Neutralization of CD95 ligand protects the liver against ischemia-reperfusion injury and prevents acute liver failure
    Authors: M Al-Saeedi, N Steinebrun, H Kudsi, N Halama, C Mogler, MW Büchler, PH Krammer, P Schemmer, M Müller
    Cell Death Dis, 2018-01-26;9(2):132.  2018-01-26
  15. In vitro assessment of anti-proliferative effect induced by ?-mangostin from Cratoxylum arborescens on HeLa cells
    Authors: AI El Habbash, N Mohd Hashi, MY Ibrahim, M Yahayu, FAE Omer, M Abd Rahman, N Nordin, GEC Lian
    PeerJ, 2017-07-21;5(0):e3460.  2017-07-21
  16. Bufalin sensitizes human bladder carcinoma cells to TRAIL-mediated apoptosis
    Authors: KH Kang, MH Han, JW Jeong, C Park, SH Lee, HW Lee, SH Hong, YH Choi, SH Hong
    Oncol Lett, 2017-05-22;14(1):853-859.  2017-05-22
  17. Induction of apoptosis by ethanol extract of Evodia rutaecarpa in HeLa human cervical cancer cells via activation of AMP-activated protein kinase
    Authors: Seon Young Park
    Biosci Trends, 2016-11-27;0(0):.  2016-11-27
  18. Chrysin induces cell apoptosis in human uveal melanoma cells via intrinsic apoptosis
    Authors: C Xue, Y Chen, DN Hu, C Iacob, C Lu, Z Huang
    Oncol Lett, 2016-10-13;12(6):4813-4820.  2016-10-13
  19. Pulchrin A, a New Natural Coumarin Derivative of Enicosanthellum pulchrum, Induces Apoptosis in Ovarian Cancer Cells via Intrinsic Pathway
    PLoS ONE, 2016-05-02;11(5):e0154023.  2016-05-02
  20. Decidualization and syndecan-1 knock down sensitize endometrial stromal cells to apoptosis induced by embryonic stimuli.
    Authors: Boeddeker S, Baston-Buest D, Fehm T, Kruessel J, Hess A
    PLoS ONE, 2015-04-01;10(4):e0121103.  2015-04-01
  21. Copper chelation selectively kills colon cancer cells through redox cycling and generation of reactive oxygen species.
    Authors: Fatfat M, Merhi R, Rahal O, Stoyanovsky D, Zaki A, Haidar H, Kagan V, Gali-Muhtasib H, Machaca K
    BMC Cancer, 2014-07-21;14(0):527.  2014-07-21
  22. Soy soluble polysaccharide induces apoptosis in HCT116 human colon cancer cells via reactive oxygen species generation.
    Authors: Ko Y, Jeong J, Choi Y, Ryu C
    Mol Med Rep, 2013-10-14;8(6):1767-72.  2013-10-14
  23. Valproic acid inhibits the growth of HeLa cervical cancer cells via caspase-dependent apoptosis.
    Authors: Han B, You B, Park W
    Oncol Rep, 2013-09-20;30(6):2999-3005.  2013-09-20
  24. Malignant melanoma cells acquire resistance to DNA interstrand cross-linking chemotherapeutics by p53-triggered upregulation of DDB2/XPC-mediated DNA repair.
    Authors: Barckhausen C, Roos W, Naumann S, Kaina B
    Oncogene, 2013-04-22;33(15):1964-74.  2013-04-22
  25. The novel carboxamide analog ITR-284 induces caspase-dependent apoptotic cell death in human hepatocellular and colorectal cancer cells.
    Authors: Liao Y, Lu C, Lai K, Yang J, Kuo S, Wen Y, Fushiya S, Wu T
    Mol Med Rep, 2013-03-05;7(5):1539-44.  2013-03-05
  26. Combination of albendazole and 2-methoxyestradiol significantly improves the survival of HCT-116 tumor-bearing nude mice.
    Authors: Ehteda, Anahid, Galettis, Peter, Pillai, Krishna, Morris, David L
    BMC Cancer, 2013-02-23;13(0):86.  2013-02-23
  27. Citrus aurantium L. exhibits apoptotic effects on U937 human leukemia cells partly through inhibition of Akt.
    Authors: Han MH, Lee WS, Lu JN
    Int. J. Oncol., 2012-02-01;40(6):2090-6.  2012-02-01
  28. A proteomic approach to the identification of molecular targets in subsequent apoptosis of HEL cells after diosgenin-induced megakaryocytic differentiation.
    Authors: Cailleteau C, Liagre B, Beneytout JL
    J. Cell. Biochem., 2009-07-01;107(4):785-96.  2009-07-01
  29. Differential response of p53 and p21 on HDAC inhibitor-mediated apoptosis in HCT116 colon cancer cells in vitro and in vivo.
    Authors: Zopf S, Neureiter D, Bouralexis S, Abt T, Glaser KB, Okamoto K, Ganslmayer M, Hahn EG, Herold C, Ocker M
    Int. J. Oncol., 2007-12-01;31(6):1391-402.  2007-12-01
  30. Enhancement of Apo2L/TRAIL-mediated cytotoxicity in esophageal cancer cells by cisplatin.
    Authors: Tsai WS, Yeow WS, Chua A, Reddy RM, Nguyen DM, Schrump DS
    Mol. Cancer Ther., 2006-12-01;5(12):2977-90.  2006-12-01
  31. EphB4 provides survival advantage to squamous cell carcinoma of the head and neck.
    Authors: Masood R, Kumar SR, Sinha UK, Crowe DL, Krasnoperov V, Reddy RK, Zozulya S, Singh J, Xia G, Broek D, Schonthal AH, Gill PS
    Int. J. Cancer, 2006-09-15;119(6):1236-48.  2006-09-15
  32. Apoptosis of human macrophages by Flt-4 signaling: implications for atherosclerotic plaque pathology.
    Authors: Schmeisser A, Christoph M, Augstein A, Marquetant R, Kasper M, Braun-Dullaeus RC, Strasser RH
    Cardiovasc. Res., 2006-06-12;71(4):774-84.  2006-06-12
  33. HIV-1 tat protein and cell proliferation and survival: a brief review.
    Authors: Gibellini D, Vitone F, Schiavone P, Re MC
    New Microbiol., 2005-04-01;28(2):95-109.  2005-04-01
  34. Suppression of graft coronary artery disease by a brief treatment with a selective epsilonPKC activator and a deltaPKC inhibitor in murine cardiac allografts.
    Authors: Tanaka M, Terry RD, Mokhtari GK, Inagaki K, Koyanagi T, Kofidis T, Mochly-Rosen D, Robbins RC
    Circulation, 2004-09-14;110(11):II194-9.  2004-09-14
  35. Cardiomyocyte-specific Bcl-2 overexpression attenuates ischemia-reperfusion injury, immune response during acute rejection, and graft coronary artery disease.
    Authors: Tanaka M, Nakae S, Terry RD, Mokhtari GK, Gunawan F, Balsam LB, Kaneda H, Kofidis T, Tsao PS, Robbins RC
    Blood, 2004-07-27;104(12):3789-96.  2004-07-27
  36. Ultraviolet light-induced apoptotic death is impaired by the HMG-CoA reductase inhibitor lovastatin.
    Authors: Bardeleben R, Kaina B, Fritz G
    Biochem. Biophys. Res. Commun., 2003-07-25;307(2):401-7.  2003-07-25
  37. Apaf-1 is a mediator of E2F-1-induced apoptosis.
    Authors: Furukawa Y, Nishimura N, Furukawa Y, Satoh M, Endo H, Iwase S, Yamada H, Matsuda M, Kano Y, Nakamura M
    J. Biol. Chem., 2002-07-30;277(42):39760-8.  2002-07-30
  38. Caspases as key executors of methyl selenium-induced apoptosis (anoikis) of DU-145 prostate cancer cells.
    Authors: Jiang C, Wang Z, Ganther H, Lu J
    Cancer Res., 2001-04-01;61(7):3062-70.  2001-04-01

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