CCMI

Catalog #: 3837 Datasheet / COA / SDS

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CCMI | CAS No. 917837-54-8 | Nicotinic (a7) Receptor Modulators

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Description: Positive allosteric modulator of α7 nAChRs

Alternative Names: XY 4083

Chemical Name: [N-(4-Chlorophenyl)]-α-[(4-chlorophenyl)-aminomethylene]-3-methyl-5-isoxazoleacetamide

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Biological Activity

CCMI is a positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptors (nAChR). Evokes positive modulation of acetylcholine (ACh)-induced EC₅ currents (EC₅₀ = 0.7 μM). Exhibits cognitive-enhancing properties in rodent models; displays no cytotoxic effects in PC12 cells or rat primary cortical neurons.

Technical Data

M.Wt:

388.25

Formula:

C₁₉H₁₅Cl₂N₃O₂

Solubility:

Soluble to 100 mM in DMSO and to 10 mM in ethanol

Storage:

Store at -20°C

CAS No:

917837-54-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Distinct profiles of α₇ nAChR positive allosteric modulation revealed by structurally diverse chemotypes.
Gronlien et al.
Mol.Pharmacol., 2007;72:715
Positive allosteric modulation of α7 neuronal nicotinic acetylcholine receptors: lack of cytotoxicity in PC12 cells and rat primary cortical neurons.
Hu et al.
Br.J.Pharmacol., 2009;158:1857

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