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CDK8/19i

Catalog #: 7372 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7372/10
7372/50
CDK8/19i | CAS No. 923596-52-5 | Cyclin-dependent Kinase Inhibitors
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Description: Potent and selective CDK8 and CDK19 inhibitor; maintains pluripotency of mouse PSCs in culture

Chemical Name: N-Propyl-3-(4-pyridinyl)imidazo[1,2-b]pyridazin-6-amine

Purity: ≥98%

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Biological Activity

CDK8/19i is a potent and selective CDK8 and CDK19 inhibitor (IC50 values are 2.9 and 14.1 nM, respectively). CDK8/19i maintains pluripotency of mouse PSCs in culture. It induces the formation of dome-shaped colonies and upregulates Nanog-GFP reporter and endogenous Nanog expression in mouse ESCs in vitro.

Technical Data

M.Wt:
253.3
Formula:
C14H15N5
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
923596-52-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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