Cerestat
Chemical Name: N-(3-Ethylphenyl)-N-methyl-N'-1-naphthalenylguanidine hydrochloride
Purity: ≥98%
Biological Activity
Cerestat is a potent and noncompetitive NMDA receptor antagonist (IC50 = 36 nM). Exhibits >70-fold selectivity for NMDA receptor over σ receptor. Neuroprotective in a rat model of focal ischemia.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Synthesis and structure-activity studies of N,N'-diarylguanidine derivatives. N-(1-naphthyl)-N'-(3-ethylphenyl)-N'-methylguanidine: a new, selective noncompetitive NMDA receptor antagonist.
Reddy et al.
J.Med.Chem., 1994;37:260 -
The N-MthD.-aspartate antagonist CNS 1102 protects cerebral gray and white matter from ischemic injury following temporary focal ischemia in rats.
Schäbitz et al.
Stroke, 2000;31:1709
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