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Cetirizine dihydrochloride

Catalog #: 2577
4 Citations Datasheet / COA / SDS

Discontinued Product

2577 has been discontinued.
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Cetirizine dihydrochloride | CAS No. 83881-52-1 | Histamine H1 Receptor Antagonists
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Description: Selective H1 antagonist
Alternative Names: P 071

Chemical Name: [2-[4-[(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetic acid dihydrochloride

Purity: ≥99%

Product Details
Citations (4)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Cetirizine dihydrochloride is a histamine H1 receptor antagonist that displays selectivity over other receptors at concentrations up to 10 μM. A non-sedating antihistamine that inhibits histamine release and eosinophil chemotaxis during secondary phase allergic response. Inhibits activation of eosinophils, neutrophils and monocytes in vivo.

Technical Data

M.Wt:
461.81
Formula:
C21H25ClN2O3.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
83881-52-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Cetirizine dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Cetirizine dihydrochloride include:

4 Citations: Showing 1 - 4

  1. Mast Cells in the Developing Brain Determine Adult Sexual Behavior.
    Authors: Lenz Et al.
    J Neurosci  2018;38:8044
  2. PARK2-mediated mitophagy is involved in regulation of HBEC senescence in COPD pathogenesis.
    Authors: Ito Et al.
    PLoS One  2015;11:547
  3. DNA repair synthesis and ligation affect the processing of excised oligonucleotides generated by human nucleotide excision repair.
    Authors: Kemp Et al.
    J Biol Chem  2014;289:26574
  4. Effects of histamine on cultured interstitial cells of cajal in murine small intestine.
    Authors: Kim Et al.
    Korean J Physiol Pharmacol  2013;17:149

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