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Cetrorelix Acetate

Catalog #: 3536 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3536/1
Cetrorelix Acetate
1 Image
Description: Potent GnRH receptor antagonist
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Biological Activity

Cetrorelix Acetate is a potent gonadotropin-releasing hormone (GnRH) receptor antagonist (KD = 0.202 nM, IC50 = 1.21 nM). Suppresses production of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland, which inhibits ovulation. Exhibits antiproliferative effects and displays efficacy against hormone-sensitive cancers in vivo. Also exhibits anxiolytic and antidepressant activity in vivo.

Technical Data

M.Wt:
1491.11
Formula:
C70H92ClN17O14.C2H4O2
Sequence:
XFASYXLRPA

(Modifications: X-1 = D-2-Nal and N-terminal Ac, Phe-2 = D-(4-Cl-Phe), Ala-3 = D-(3-Pyridyl-Ala), X-6 = D-Cit, Ala-10 = D-Ala and C-terminal amide)

Solubility:
Soluble in water
Storage:
Store at -20°C
CAS No:
145672-81-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Knockdown of Hepatic Gonadotropin-Releasing Hormone by Vivo-Morpholino Decreases Liver Fibrosis in Multidrug Resistance Gene 2 Knockout Mice by Down-Regulation of miR-200b
    K Kyritsi, F Meng, T Zhou, N Wu, J Venter, H Francis, L Kennedy, P Onori, A Franchitto, F Bernuzzi, P Invernizzi, K McDaniel, R Mancinelli, D Alvaro, E Gaudio, G Alpini, S Glaser
    Am. J. Pathol., 2017;0(0):.
  2. Characterization of gonadotropin-releasing hormone analogs based on a sensitive cellular luciferase reporter gene assay.
    Beckers et al.
    Anal.Biochem., 1997;251:17
  3. Role of gonadotropin-releasing hormone (GnRH) in ovarian cancer.
    Grundker and Emons
    Reprod.Biol.Endocrinol., 2003;1:65
  4. Effects of the LHRH antagonist cetro. on the brain function in mice.
    Telegdy et al.
    Neuropeptides, 2009;43:229

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