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cGMP Parameter Assay Kit

Catalog #: KGE003
54 Citations Datasheet / COA / SDS
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KGE003 has been discontinued.
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Multi-species cGMP ELISA Cell Lysate Standard Curve
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Product Details
Procedure
Citations (54)
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Summary Precision Recovery Linearity Data Examples Product Datasheets Preparation and Storage Background Related Research Areas

cGMP Parameter Assay Kit Summary

Format
96-well strip plate
Assay Length
3.5 hours
Sample Type & Volume Required Per Well
Cell Culture Supernates (100 uL), Cell Lysates (100 uL), EDTA Plasma (100 uL), Saliva (100 uL), Urine (100 uL)
Sensitivity
3.06 pmol/mL
Assay Range
2.1 - 500 pmol/mL (Cell Culture Supernates, Cell Lysates, EDTA Plasma, Saliva, Urine)
Specificity
Measures cyclic GMP levels in various samples
Cross-reactivity
< 0.5% cross-reactivity observed with available related molecules.Cross-species reactivity not tested.
Interference
No significant interference observed with available related molecules.

Product Summary

The Parameter cGMP Immunoassay is a 3.5 hour competitive enzyme immunoassay designed to measure cGMP in cell culture supernates, plasma, saliva, urine, and cell lysates.

Precision

Intra-Assay Precision (Precision within an assay) Three samples of known concentration were tested on one plate to assess intra-assay precision
Inter-Assay Precision (Precision between assays) Three samples of known concentration were tested in separate assays to assess inter-assay precision

Cell Culture Supernates, EDTA Plasma, Saliva, Urine

Intra-Assay Precision Inter-Assay Precision
Sample 1 2 3
n 20 20 20
Mean (pg/mL) 85.2 184 265
Standard Deviation 6.9 12.5 14
CV% 8.1 6.8 5.3

Cell Lysates

Intra-Assay Precision Inter-Assay Precision
Sample 1 2 3 1 2 3
n 20 20 20 40 40 40
Mean (pg/mL) 57 72 178 52 67 195
Standard Deviation 2.2 4 9.5 4 4.4 12.7
CV% 3.9 5.6 5.3 7.7 6.6 6.5

Recovery

The recovery of cGMP spiked to levels throughout the range of the assay in various matrices was evaluated.

Sample Type Average % Recovery Range %
Cell Culture Media (n=4) 100 91-108
Cell Lysates (n=1) 92 80-98
EDTA Plasma (n=4) 91 74-105
Saliva (n=4) 102 80-123
Urine (n=4) 90 77-98

Linearity

To assess the linearity of the assay, samples containing and/or spiked with high concentrations of cGMP were serially diluted with Calibrator Diluent to produce samples with values within the dynamic range of the assay.
Multi-species cGMP ELISA Linearity

Scientific Data

N/A Multi-species cGMP ELISA Cell Lysate Standard Curve View Larger

Multi-species cGMP ELISA Cell Lysate Standard Curve

N/A Multi-species cGMP ELISA Cell Culture Supernate/Plasma/Saliva/Urine Standard Curve View Larger

Multi-species cGMP ELISA Cell Culture Supernate/Plasma/Saliva/Urine Standard Curve

Product Datasheets

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Product Datasheet
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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: cGMP

Guanosine 3, 5-cyclic monophosphate (cGMP) is formed via the action of guanylate cyclase on GTP. cGMP is present at levels typically 10-100 fold lower than cAMP in most tissues. A variety of stimuli including acetylcholine, insulin, oxytocin, serotonin, and histamine will cause an increase in cGMP levels. Various stimulators of guanylate cyclase (e.g. vasodilators) as well as peptides that relax smooth muscle also increase cGMP concentrations.

Long Name:
Cyclic GMP
Alternate Names:
cGMP
&#9888; WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Assay Procedure

Refer to the product for complete assay procedure.

Bring all reagents and samples to room temperature before use. It is recommended that all samples, standards, and controls be assayed in duplicate.
  1.   Prepare all reagents, standard dilutions, and samples as directed in the product insert.
  2.   Remove excess microplate strips from the plate frame, return them to the foil pouch containing the desiccant pack, and reseal.
    3. 150 µL Diluent to NSB wells & 100 µL Diluent to B0 wells
  3.   Add 150 µL of the appropriate diluent to the non-specific binding (NSB) wells and 100 µL of the appropriate diluent to the zero standard (B0) wells.
    4. 100 µL Standard, Control, or Sample
  4.   Add 100 µL of Standard, Control, or sample to the remaining wells.
    5. 50 µL Conjugate
  5.   Add 50 µL of Conjugate to each well.
    6. 50 µL Primary Antibody Solution
  6.   Add 50 µL of Primary Antibody Solution to each well (except the NSB wells).
  7.   Cover with a plate sealer, and incubate at room temperature for 3 hours on a horizontal orbital microplate shaker.
  8.   Aspirate each well and wash, repeating the process 3 times for a total of 4 washes.
    9. 200 µL Substrate Solution
  9.   Add 200 µL Substrate Solution to each well. Incubate at room temperature for 30 minutes on the benchtop. PROTECT FROM LIGHT.
    10. 50 µL Stop Solution
  10. Add 50 µL of Stop Solution to each well. Read at 450 nm within 30 minutes. Set wavelength correction to 540 nm or 570 nm.

Citations for cGMP Parameter Assay Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

54 Citations: Showing 1 - 10
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  1. Inducible over-expression of cardiac Nos1ap causes short QT syndrome in transgenic mice
    Authors: M Jänsch, LT Lubomirov, M Trum, T Williams, J Schmitt, K Schuh, F Qadri, LS Maier, M Bader, O Ritter
    FEBS Open Bio, 2022-11-27;0(0):.
    Species: Mouse
    Sample Types: Tissue Homogenates
  2. Somatic cell hemoglobin modulates nitrogen oxide metabolism in the human airway epithelium
    Authors: N Marozkina, L Smith, Y Zhao, J Zein, JF Chmiel, J Kim, J Kiselar, MD Davis, RS Cunningham, SH Randell, B Gaston
    Scientific Reports, 2021-07-29;11(1):15498.
    Species: Human
    Sample Types: Cell Culture Supernates
  3. Cardiovascular Risk and Endothelial Dysfunction in Primary Sjogren Syndrome Is Related to the Disease Activity
    Authors: A ?uczak, R Ma?ecki, M Kulus, M Madej, E Szahidewic, A Doroszko
    Nutrients, 2021-06-17;13(6):.
    Species: Human
    Sample Types: Plasma
  4. Synthesis and pharmacological evaluation of pomalidomide derivatives useful for sickle cell disease treatment
    Authors: TRF de Melo, BM Dulmovits, GFDS Fernandes, CM de Souza, C Lanaro, M He, Y Al Abed, MC Chung, L Blanc, FF Costa, JL Dos Santos
    Bioorganic chemistry, 2021-06-10;114(0):105077.
    Species: Human
    Sample Types: Cell Lysates
  5. Aortic disease in Marfan syndrome is caused by overactivation of sGC-PRKG signaling by NO
    Authors: A de la Fuen, M Toral, A Alfayate, MJ Ruiz-Rodrí, E Bonzón-Kul, G Teixido-Tu, S Martínez-M, MJ Méndez-Oli, D López-Made, I González-V, E Garcia-Izq, S Mingo, CE Martín, L Muiño-Mosq, J De Backer, JF Nistal, A Forteza, A Evangelist, J Vázquez, MR Campanero, JM Redondo
    Nature Communications, 2021-05-11;12(1):2628.
    Species: Human, Mouse
    Sample Types: Plasma
  6. 8-Alkylmercaptocaffeine derivatives: antioxidant, molecular docking, and in-vitro cytotoxicity studies
    Authors: S Sargazi, S Shahraki, O Shahraki, F Zargari, R Sheervalil, S Maghsoudi, MN Soltani Ra, R Saravani
    Bioorganic chemistry, 2021-04-09;111(0):104900.
    Species: Human
    Sample Types: Cell Lysates
  7. Divergent trajectories of cellular bioenergetics, intermediary metabolism and systemic redox status in survivors and non-survivors of critical illness
    Authors: HT McKenna, KA O'Brien, BO Fernandez, M Minnion, A Tod, BD McNally, JA West, JL Griffin, MP Grocott, MG Mythen, M Feelisch, AJ Murray, DS Martin
    Redox Biology, 2021-02-20;41(0):101907.
    Species: Human
    Sample Types: Plasma
  8. Refinement of the CS6-expressing enterotoxigenic Escherichia coli strain B7A human challenge model: A randomized trial
    Authors: KR Talaat, CK Porter, KM Jaep, CA Duplessis, RL Gutierrez, M Maciel, B Adjoodani, B Feijoo, S Chakrabort, J Brubaker, SA Trop, MS Riddle, SS Joseph, AL Bourgeois, MG Prouty
    PLoS ONE, 2020-12-02;15(12):e0239888.
    Species: Human
    Sample Types:
  9. Exosomes derived from smooth muscle cells ameliorate diabetes-induced erectile dysfunction by inhibiting fibrosis and modulating the NO/cGMP pathway
    Authors: J Song, T Sun, Z Tang, Y Ruan, K Liu, K Rao, R Lan, S Wang, T Wang, J Liu
    J Cell Mol Med, 2020-10-03;0(0):.
    Species: Rat
    Sample Types: Tissue Homogenates
  10. Circulating miRNAs Associated with Dysregulated Vascular and Trophoblast Function as Target-Based Diagnostic Biomarkers for Preeclampsia
    Authors: S Kim, M Park, JY Kim, T Kim, JY Hwang, KS Ha, MH Won, S Ryoo, YG Kwon, YM Kim
    Cells, 2020-08-31;9(9):.
    Species: Human
    Sample Types: Serum
  11. Enhanced Cardiomyocyte Function in Hypertensive Rats With Diastolic Dysfunction and Human Heart Failure Patients After Acute Treatment With Soluble Guanylyl Cyclase (sGC) Activator
    Authors: D Kolijn, Á Kovács, M Herwig, M Lódi, M Sieme, A Alhaj, P Sandner, Z Papp, PH Reusch, P Haldenwang, I Falcão-Pir, WA Linke, K Jaquet, S Van Lintho, A Mügge, C Tschöpe, N Hamdani
    Front Physiol, 2020-05-25;11(0):345.
    Species: Human
    Sample Types: Tissue Homogenate
  12. Sini-San Regulates the NO-cGMP-PKG Pathway in the Spinal Dorsal Horn in a Modified Rat Model of Functional Dyspepsia
    Authors: Z Wu, X Lu, S Zhang, C Zhu
    Evid Based Complement Alternat Med, 2020-03-31;2020(0):3575231.
    Species: Rat
    Sample Types: Tissue Homogenates
  13. Expression and Secretion of an Atrial Natriuretic Peptide in Beige-Like 3T3-L1 Adipocytes
    Authors: IS Bae, SH Kim
    Int J Mol Sci, 2019-12-05;20(24):.
    Species: Human
    Sample Types: Cell Lysates
  14. Regulation and Function of C-Type Natriuretic Peptide (CNP) in Gonadotrope-Derived Cell Lines
    Authors: SM Mirczuk, AJ Lessey, AR Catterick, RM Perrett, CJ Scudder, JE Read, VJ Lipscomb, SJ Niessen, AJ Childs, CA McArdle, IM McGonnell, RC Fowkes
    Cells, 2019-09-14;8(9):.
    Species: Human
    Sample Types: Cell Lysates
  15. Low-Dose Carbon Monoxide Inhibits Rhinovirus Replication in Human Alveolar and Airway Epithelial Cells
    Authors: X Deng, H Yasuda, T Sasaki, M Yamaya
    Tohoku J. Exp. Med., 2019-04-01;247(4):215-222.
    Species: Human
    Sample Types: Cell Culture Supernates
  16. Cardiorenal and endocrine effects of synthetic canine BNP1-32 in dogs with compensated congestive heart failure caused by myxomatous mitral valve disease
    Authors: M Yata, HS Kooistra, NJ Beijerink
    J. Vet. Intern. Med., 2019-01-31;0(0):.
    Species: Canine
    Sample Types: Urine
  17. Pushing arterial-venous plasma biomarkers to new heights: A model for personalised redox metabolomics?
    Authors: AF Cumpstey, M Minnion, BO Fernandez, M Mikus-Leli, K Mitchell, DS Martin, MPW Grocott, M Feelisch
    Redox Biol, 2019-01-22;21(0):101113.
    Species: Human
    Sample Types: Plasma
  18. NF-?B-Responsive miRNA-31-5p elicits endothelial dysfunction associated with preeclampsia via downregulation of endothelial nitric oxide synthase
    Authors: S Kim, KS Lee, S Choi, J Kim, DK Lee, M Park, W Park, TH Kim, JY Hwang, MH Won, H Lee, S Ryoo, KS Ha, YG Kwon, YM Kim
    J. Biol. Chem., 2018-10-02;0(0):.
    Species: Human
    Sample Types: Cell Lysates
  19. Possible Enzymatic Downregulation of the Natriuretic Peptide System in Patients with Reduced Systolic Function and Heart Failure: A Pilot Study
    Authors: SS Zaidi, RD Ward, K Ramanathan, X Yu, IP Gladysheva, GL Reed
    Biomed Res Int, 2018-07-26;2018(0):7279036.
    Species: Human
    Sample Types: Plasma
  20. MicroRNA-133a Impairs Perfusion Recovery after Hindlimb Ischemia in Diabetic Mice
    Authors: L Chen, C Liu, D Sun, T Wang, L Zhao, W Chen, M Yuan, J Wang, W Lu
    Biosci. Rep., 2018-07-02;0(0):.
    Species: Mouse
    Sample Types: Tissue Homogenates
  21. Effect of neprilysin inhibition on renal function in patients with type 2 diabetes and chronic heart failure who are receiving target doses of inhibitors of the renin-angiotensin system: a secondary analysis of the PARADIGM-HF trial
    Authors: M Packer, B Claggett, MP Lefkowitz, JJV McMurray, JL Rouleau, SD Solomon, MR Zile
    Lancet Diabetes Endocrinol, 2018-04-13;0(0):.
    Species: Human
    Sample Types: Urine
  22. Xyloketal B exerts antihypertensive effect in renovascular hypertensive rats via the NO-sGC-cGMP pathway and calcium signaling
    Authors: LY Zhao, J Li, XQ Huang, GH Wang, XF Lv, WF Meng, WL Chen, JY Pang, YC Lin, HS Sun, GL Wang, YM Du
    Acta Pharmacol. Sin., 2018-03-29;0(0):.
    Species: Rat
    Sample Types: Cell Lysates
  23. Fasudil and DETA NONOate, loaded in a peptide-modified liposomal carrier, slows PAH progression upon pulmonary delivery
    Authors: J Rashid, K Nahar, S Raut, A Keshavarz, F Ahsan
    Mol. Pharm., 2018-03-26;0(0):.
    Species: Human
    Sample Types: Cell Lysates
  24. Novel H2S-NO hybrid molecule (ZYZ-803) promoted synergistic effects against heart failure
    Authors: D Wu, Q Hu, Y Xiong, D Zhu, Y Mao, YZ Zhu
    Redox Biol, 2017-12-14;15(0):243-252.
    Species: Mouse
    Sample Types: Plasma
  25. Carbon monoxide prevents TNF-?-induced eNOS downregulation by inhibiting NF-?B-responsive miR-155-5p biogenesis
    Authors: S Choi, J Kim, JH Kim, DK Lee, W Park, M Park, S Kim, JY Hwang, MH Won, YK Choi, S Ryoo, KS Ha, YG Kwon, YM Kim
    Exp. Mol. Med., 2017-11-24;49(11):e403.
    Species: Human
    Sample Types: Cell Lysates
  26. REM sleep deprivation induces endothelial dysfunction and hypertension in middle-aged rats: Roles of the eNOS/NO/cGMP pathway and supplementation with L-arginine
    Authors: J Jiang, Z Gan, Y Li, W Zhao, H Li, JP Zheng, Y Ke
    PLoS ONE, 2017-08-15;12(8):e0182746.
    Species: Rat
    Sample Types: Tissue Homogenates
  27. Does hypoxia play a role in the development of sarcopenia in humans? Mechanistic insights from the Caudwell Xtreme Everest Expedition
    Authors: L Wandrag, M Siervo, HL Riley, M Khosravi, BO Fernandez, CA Leckstrom, DS Martin, K Mitchell, DZH Levett, HE Montgomery, MG Mythen, MA Stroud, MPW Grocott, M Feelisch, Caudwell X
    Redox Biol, 2017-05-08;13(0):60-68.
    Species: Human
    Sample Types: Plasma
  28. Epigallocatechin-3-gallate ameliorates erectile function in aged rats via regulation of PRMT1/DDAH/ADMA/NOS metabolism pathway
    Authors: D Chen, KQ Zhang, B Li, DQ Sun, H Zhang, Q Fu
    Asian J Androl, 2017-05-01;0(0):.
    Species: Rat
    Sample Types: Tissue Homogenates
  29. In vitro and in vivo investigation of natural compounds from seed extract of Mucuna pruriens lacking l-DOPA for the treatment of erectile dysfunction
    Authors: N Duangnin, T Phitak, P Pothacharo, P Kongtawele
    Asian Pac J Trop Med, 2017-03-07;10(3):238-252.
    Species: Human, Rat
    Sample Types: Cell Lysates
  30. Critical role of vascular peroxidase 1 in regulating endothelial nitric oxide synthase
    Authors: Z Liu, Y Liu, Q Xu, H Peng, Y Tang, T Yang, Z Yu, G Cheng, G Zhang, R Shi
    Redox Biol, 2017-02-27;12(0):226-232.
    Species: Human
    Sample Types: Cell Lysates
  31. Inhibition of Phosphodiesterase 5 and Increasing the Level of Cyclic Guanosine 3',5' Monophosphate by Hydroalcoholic Achillea wilhelmsii C. Koch Extract in Human Breast Cancer Cell Lines MCF-7 and MDA-Mb-468
    Authors: R Saravani, HR Galavi, A Shahraki
    Breast Cancer (Auckl), 2017-02-23;11(0):1178223417690.
    Species: Human
    Sample Types: Cell Lysates
  32. Angiotensin-(1-7) Downregulates Diabetes-Induced cGMP Phosphodiesterase Activation in Rat Corpus Cavernosum
    Authors: GS Dhaunsi, M Yousif, B Makki, S Akhtar, IF Benter
    Biomed Res Int, 2017-02-19;2017(0):5084961.
    Species: Rat
    Sample Types: Tissue Homogenates
  33. Alternative hematological and vascular adaptive responses to high-altitude hypoxia in East African Highlanders
    Authors: Hoi I Cheong
    Am. J. Physiol. Lung Cell Mol. Physiol, 2016-12-15;0(0):ajplung.00451.
    Species: Human
    Sample Types: Urine
  34. Lycopene Ameliorates Transplant Arteriosclerosis in Vascular Allograft Transplantation by Regulating the NO/cGMP Pathways and Rho-Associated Kinases Expression
    Oxid Med Cell Longev, 2016-12-05;2016(0):3128280.
    Species: Rat
    Sample Types: Plasma
  35. Unbalanced Oxidant-Antioxidant Status: A Potential Therapeutic Target for Coronary Chronic Total Occlusion in Very Old Patients
    Oxid Med Cell Longev, 2016-12-01;2016(0):4910829.
    Species: Rat
    Sample Types: Tissue Homogenates
  36. S-palmitoylation of a Novel Site in the ?2-adrenergic Receptor Associated with a Novel Intracellular Itinerary
    J Biol Chem, 2016-08-01;0(0):.
    Species: Human
    Sample Types: Cell Lysates
  37. Asymmetric Dimethylarginine Limits the Efficacy of Simvastatin Activating Endothelial Nitric Oxide Synthase
    Authors: CP Hsu, JF Zhao, SJ Lin, SK Shyue, BC Guo, TM Lu, TS Lee
    J Am Heart Assoc, 2016-04-18;5(4):.
    Species: Human
    Sample Types: Cell Culture Supernates
  38. Impaired sodium dependent adaptation of arterial stiffness in formerly preeclamptic women: The RETAP - vascular study
    Authors: AM van der Gr, ND Paauw, TJ Toering, M Feelisch, MM Faas, TR Sutton, MM Minnion, JD Lefrandt, SA Scherjon, A Franx, G Navis, AT Lely
    Am J Physiol Heart Circ Physiol, 2016-04-08;0(0):ajpheart.0001.
    Species: Human
    Sample Types: Plasma
  39. The effects of phosphodiesterase-5 inhibitor sildenafil against post-resuscitation myocardial and intestinal microcirculatory dysfunction by attenuating apoptosis and regulating microRNAs expression: essential role of nitric oxide syntheses signaling.
    Authors: Zhang Q, Wang G, Yuan W, Wu J, Wang M, Li C
    J Transl Med, 2015-06-04;13(0):177.
    Species: Porcine
    Sample Types: Tissue Homogenates
  40. Simultaneous exposure to Escherichia coli heat-labile and heat-stable enterotoxins increases fluid secretion and alters cyclic nucleotide and cytokine production by intestinal epithelial cells.
    Authors: Read L, Hahn R, Thompson C, Bauer D, Norton E, Clements J
    Infect Immun, 2014-10-06;82(12):5308-16.
    Species: Human
    Sample Types: Cell Lysates
  41. Critical role of exogenous nitric oxide in ROCK activity in vascular smooth muscle cells.
    Authors: Maruhashi, Tatsuya, Noma, Kensuke, Iwamoto, Yumiko, Iwamoto, Akimichi, Oda, Nozomu, Kajikawa, Masato, Matsumoto, Takeshi, Hidaka, Takayuki, Kihara, Yasuki, Chayama, Kazuaki, Nakashima, Ayumu, Goto, Chikara, Liao, James K, Higashi, Yukihito
    PLoS ONE, 2014-10-03;9(10):e109017.
    Species: Human, Mouse
    Sample Types: Cell Lysates
  42. MicroRNA-378 controls classical brown fat expansion to counteract obesity.
    Authors: Pan, Dongning, Mao, Chunxiao, Quattrochi, Brian, Friedline, Randall, Zhu, Lihua J, Jung, Dae Youn, Kim, Jason K, Lewis, Brian, Wang, Yong-Xu
    Nat Commun, 2014-08-22;5(0):4725.
    Species: Mouse
    Sample Types: Tissue Homogenates
  43. Telmisartan attenuates colon inflammation, oxidative perturbations and apoptosis in a rat model of experimental inflammatory bowel disease.
    Authors: Arab H, Al-Shorbagy M, Abdallah D, Nassar N
    PLoS ONE, 2014-05-15;9(5):e97193.
    Species: Human
    Sample Types: Cell Culture Supernates
  44. Telmisartan activates endothelial nitric oxide synthase via Ser1177 phosphorylation in vascular endothelial cells.
    Authors: Myojo, Masahiro, Nagata, Daisuke, Fujita, Daishi, Kiyosue, Arihiro, Takahashi, Masao, Satonaka, Hiroshi, Morishita, Yoshiyuk, Akimoto, Tetsu, Nagai, Ryozo, Komuro, Issei, Hirata, Yasunobu
    PLoS ONE, 2014-05-14;9(5):e96948.
    Species: Human
    Sample Types: Cell Lysates
  45. Resolvin D1 stimulates alveolar fluid clearance through alveolar epithelial sodium channel, Na,K-ATPase via ALX/cAMP/PI3K pathway in lipopolysaccharide-induced acute lung injury.
    Authors: Wang Q, Zheng X, Cheng Y, Zhang Y, Wen H, Tao Z, Li H, Hao Y, Gao Y, Yang L, Smith F, Huang C, Jin S
    J Immunol, 2014-03-19;192(8):3765-77.
    Species: Rat
    Sample Types: Cell Lysates
  46. Oxygen mediates vascular smooth muscle relaxation in hypoxia.
    Authors: Dada, Jessica, Pinder, Andrew G, Lang, Derek, James, Philip E
    PLoS ONE, 2013-02-22;8(2):e57162.
  47. Decompensated heart failure is associated with reduced corin levels and decreased cleavage of pro-atrial natriuretic peptide.
    Authors: Ibebuogu UN, Gladysheva IP, Houng AK
    Circ Heart Fail, 2011-01-07;4(2):114-20.
    Species: Human
    Sample Types: Plasma
  48. The role of interleukin-6 in UVA protection against UVB-induced immunosuppression.
    Authors: Reeve VE, Tyrrell RM, Allanson M, Domanski D, Blyth L
    J. Invest. Dermatol., 2008-12-25;129(6):1539-46.
    Species: Mouse
    Sample Types: Tissue Homogenates
  49. Decreased nitric oxide products in the urine of patients undergoing cardiac surgery.
    Authors: Lema G, Urzua J, Jalil R, Canessa R, Vogel A, Moran S, Fajuri A, Carvajal C, Aeschlimann N, Jaque MP
    J. Cardiothorac. Vasc. Anesth., 2008-11-20;23(2):188-94.
    Species: Human
    Sample Types: Urine
  50. Thiophenecarboxylate suppressor of cyclic nucleotides discovered in a small-molecule screen blocks toxin-induced intestinal fluid secretion.
    Authors: Tradtrantip L, Yangthara B, Padmawar P, Morrison C, Verkman AS
    Mol. Pharmacol., 2008-09-29;75(1):134-42.
    Species: Hamster
    Sample Types: Cell Lysates
  51. cGMP-independent anti-tumour actions of the inhibitor of soluble guanylyl cyclase, ODQ, in prostate cancer cell lines.
    Authors: Haramis G, Zhou Z, Pyriochou A, Koutsilieris M, Roussos C, Papapetropoulos A
    Br. J. Pharmacol., 2008-08-11;155(6):804-13.
    Species: Human
    Sample Types: Cell Culture Supernates
  52. Hematologic, biochemical, and cardiopulmonary effects of L-arginine supplementation or phosphodiesterase 5 inhibition in patients with sickle cell disease who are on hydroxyurea therapy.
    Authors: Little JA, Hauser KP, Martyr SE, Harris A, Maric I, Morris CR, Suh JH, Taylor J, Castro O, Machado R, Kato G, Gladwin MT
    Eur. J. Haematol., 2008-02-10;82(4):315-21.
    Species: Human
    Sample Types: Plasma
  53. Terfenadine-induced apoptosis in human melanoma cells is mediated through Ca2+ homeostasis modulation and tyrosine kinase activity, independently of H1 histamine receptors.
    Authors: Jangi SM, Ruiz-Larrea MB, Nicolau-Galmes F, Andollo N, Arroyo-Berdugo Y, Ortega-Martinez I, Diaz-Perez JL, Boyano MD
    Carcinogenesis, 2008-01-03;29(3):500-9.
    Species: Human
    Sample Types: Cell Lysates
  54. Successive action of meprin A and neprilysin catabolizes B-type natriuretic peptide.
    Authors: Pankow K, Wang Y, Gembardt F, Krause E, Sun X, Krause G, Schultheiss HP, Siems WE, Walther T
    Circ. Res., 2007-09-06;101(9):875-82.
    Species: Human, Mouse
    Sample Types: Cell Lysates

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