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CGP 53353

Catalog #: 2442
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2442/10
CGP 53353 | CAS No. 145915-60-2 | Protein Kinase C Inhibitors
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Description: Selective inhibitor of PKCβII

Chemical Name: 5,6-bis[(4-Fluorophenyl)amino]-1H-isoindole-1,3(2H)-dione

Purity: ≥99%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

CGP 53353 is a selective inhibitor of PKCβII (IC50 values are 0.41 and 3.8 μM for PKCβII and PKCβI respectively). Also inhibits prionogenic Sup35 fibrillization (IC50 ~ 3.4 μM) and inhibits de novo Aβ42 assembly in vitro.

Technical Data

M.Wt:
365.34
Formula:
C20H13F2N3O2
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
145915-60-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Selective inhibition of protein kinase Cβ2 prevents acute effects of high glucose on vascular cell adhesion molecule-1 expression in human endothelial cells.
    Kouroedov et al.
    Circulation, 2004;110:91
  2. Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs.
    Wang et al.
    Proc.Natl.Acad.Sci.USA, 2008;105:7159

Product Datasheets

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Citations for CGP 53353

The citations listed below are publications that use Tocris products. Selected citations for CGP 53353 include:

3 Citations: Showing 1 - 3

  1. PKCβII acts downstream of chemoattractant receptors and mTORC2 to regulate cAMP production and myosin II activity in neutrophils.
    Authors: Liu Et al.
    Mol Biol Cell  2014;25:1446
  2. Stanniocalcin-1 promotes tumor angiogenesis through up-regulation of VEGF in gastric cancer cells.
    Authors: He Et al.
    J Neurosci  2011;18:39
  3. Aldose reductase-regulated tumor necrosis factor-α production is essential for high glucose-induced vascular smooth muscle cell growth.
    Authors: Ramana Et al.
    Endocrinology  2007;148:4371

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