CGP 74514 dihydrochloride
Chemical Name: rel-N2-[(1R,2S)-2-Aminocyclohexyl]-N6-(3-chlorophenyl)-9-ethyl-9H-purine-2,6-diamine dihydrochloride
Purity: ≥98%
Biological Activity
CGP 74514 dihydrochloride is a potent cdk1 inhibitor (IC50 = 25 nM). Reduces Akt phosphorylation and increases mitochondrial damage in leukemia cells in vitro in combination with LY 294002.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process.
Yu et al.
Cancer Res., 2013;63:1822 -
Structure-based design of potent CDK1 inhibitors derived from olomoucine.
Furet et al.
J.Comput.Aided Mol.Des., 2000;14:403
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