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CGRP 8-37 (rat)

Catalog #: 1169
5 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1169/500U
CGRP 8-37 (rat)
1 Image
Description: CGRP antagonist
Alternative Names: Calcitonin Gene-Related Peptide 8-37 (rat)

Purity: ≥95%

Product Details
Citations (5)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

CGRP 8-37 (rat) is a peptide antagonist for CGRP1 receptors.

Technical Data

M.Wt:
3127.5
Formula:
C138H224N42O41
Sequence:
VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF

(Modification: Phe-30 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
129121-73-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Critical role of calcitonin gene-related peptide receptors in cortical spreading depression.
    Tozzi A, de Iure A, Di Filippo M, Costa C, Caproni S, Pisani A, Bonsi P, Picconi B, Cupini L, Materazzi S, Geppetti P, Sarchielli P, Calabresi P
    Proc Natl Acad Sci U S A, 2012;109(46):18985-90.
  2. Pharmacology of receptors for calcitonin gene-related peptide and amylin.
    Poyner
    TiPS, 1995;16:424
  3. Structural determinants for binding to CGRP receptors expressed by human SK-N-MC and Col 29 cells: studies with chimeric and other peptides.
    Poyner et al.
    Br.J.Pharmacol., 1998;124:1659
  4. Pharmacological characterization of CGRP receptors mediating relaxation of the rat pulmonary artery and inhibition of twitch responses of the rat vas deferens.
    Wisskirchen et al.
    Br.J.Pharmacol., 1998;123:1673

Product Datasheets

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Citations for CGRP 8-37 (rat)

The citations listed below are publications that use Tocris products. Selected citations for CGRP 8-37 (rat) include:

5 Citations: Showing 1 - 5

  1. Role of intraganglionic transmission in the trigeminovascular pathway.
    Authors: Zhang Et al.
    Mol Pain  2019;15:1744806919836570
  2. Optogenetic Inhibition of CGRPα Sensory Neurons Reveals Their Distinct Roles in Neuropathic and Incisional Pain.
    Authors: Cowie Et al.
    J Neurosci  2018;38:5807
  3. Critical role of calcitonin gene-related peptide receptors in cortical spreading depression.
    Authors: Tozzi Et al.
    Proc Natl Acad Sci U S A  2012;109:18985
  4. Early and late contributions of glutamate and CGRP to mechanical sensitization by endothelin-1.
    Authors: Khodorova Et al.
    J Pain  2009;10:740
  5. Orexin 1 receptor activation attenuates neurogenic dural vasodilation in an animal model of trigeminovascular nociception.
    Authors: Holland Et al.
    J Cell Mol Med  2005;315:1380

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