CGRP (rat)

Catalog #: 1161
5 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
1161/100U

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Description: Potent vasodilator

Alternative Names: Calcitonin Gene-Related Peptide (rat)

Purity: ≥95%

View All Products for Calcitonin and Related Receptor Agonists

Product Details

Citations (5)

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

CGRP (rat) is an endogenous neuropeptide; potent vasodilator which also exerts cardiovascular, pro-inflammatory and metabolic effects.

Technical Data

M.Wt:

3807

Formula:

C₁₆₂H₂₆₂N₅₀O₅₂S₂

Sequence:

SCNTATCVTHRLAGLLSRSGGVVKDNFVPTNVGSEAF

(Modifications: Disulfide bridge: 2-7, Phe-37 = C-terminal amide)

Solubility:

Soluble to 0.80 mg/ml in water

Purity:

≥95%

Storage:

Store at -20°C

CAS No:

83651-90-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Calcitonin gene-related peptide is a potent vasodilator.
Brain et al.
Nature, 1985;313:54
Calcitonin gene-related peptide as a GH secretagogue in human and rat pituitary somatotrophs.
Nakamura et al.
Brain Res., 1998;807:203
Pharmacology of receptors for calcitonin gene-related peptide and amylin.
Poyner
TiPS, 1995;16:424
Isolation and characterization of human calcitonin gene-related peptide.
Morris et al.
Nature, 1984;308:746
Calcitonin gene-related peptide potentiates nicotinic acetylcholine receptor-operated slow Ca²⁺ mobilization at mouse muscle endplates.
Salim et al.
Br.J.Pharmacol., 1998;125:277
Pseudomonas aeruginosa-induced nociceptor activation increases susceptibility to infection
T Lin, D Quellier, J Lamb, T Voisin, P Baral, F Bock, A Schönberg, R Mirchev, G Pier, I Chiu, M Gadjeva
PloS Pathogens, 2021;17(5):e1009557.

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M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for CGRP (rat)

The citations listed below are publications that use Tocris products. Selected citations for CGRP (rat) include:

5 Citations: Showing 1 - 5

Neuropeptide-induced modulation of carcinogenesis in a metastatic breast cancer cell line (MDA-MB-231LUC+).
Authors: Gutierrez and Boada
Cancer Cell Int 2019;18:216
Shear stress-induced endothelial adrenomedullin signaling regulates vascular tone and blood pressure.
Authors: Iring Et al.
J Clin Invest 2019;130:2775
Distinct calcitonin gene-related peptide expression pattern in primary afferents contribute to different neuropathic symptoms following chronic constriction or crush injuries to the rat sciatic nerve.
Authors: Zou Et al.
Mol Pain 2016;12:1
Release of glutamate and CGRP from trigeminal ganglion neurons: Role of calcium channels and 5-HT1 receptor signaling.
Authors: Xiao Et al.
Elife 2008;4:12
Orexin 1 receptor activation attenuates neurogenic dural vasodilation in an animal model of trigeminovascular nociception.
Authors: Holland Et al.
Mol Pain 2005;315:1380

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