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CGS 19755

Catalog #: 1241
4 Citations Datasheet / COA / SDS
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1241/50
CGS 19755 | CAS No. 110347-85-8 | NMDA Receptor Antagonists
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Description: Potent competitive NMDA antagonist

Chemical Name: cis-4-[Phosphomethyl]-piperidine-2-carboxylic acid

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Citations (4)
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Biological Activity

CGS 19755 is a potent, competitive NMDA receptor antagonist. Anticonvulsant and neuroprotective.

Technical Data

M.Wt:
223.17
Formula:
C7H14NO5P
Solubility:
Soluble to 25 mM in water
Storage:
Store at RT
CAS No:
110347-85-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Potentiation of NMDA receptor-dependent cell responses by extracellular high mobility group box 1 protein.
    Pedrazzi, Marco, Averna, Monica, Sparatore, Bianca, Patrone, Mauro, Salamino, Franca, Marcoli, Manuela, Maura, Guido, Cervetto, Chiara, Frattaroli, Daniela, Pontremoli, Sandro, Melloni, Edon
    PLoS ONE, 2012;7(8):e44518.
  2. Behavioral pharmacological profile of CGS 19755, a competitive antagonist at N-MthD.-aspartate receptors.
    Bennett et al.
    J.Pharmacol.Exp.Ther., 1989;250:454
  3. CGS 19755, a selective and competitive N-MthD.-aspartate-type excitatory amino acid receptor antagonist.
    Lehmann et al.
    J.Pharmacol.Exp.Ther., 1988;246:65
  4. Correlation of CGS 19755 neuroprotection against in vivo excitotoxicity and focal cerebral ischemia.
    Perez-Pinzon et al.
    J.Cereb.Blood Flow Metab., 1995;15:865

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Citations for CGS 19755

The citations listed below are publications that use Tocris products. Selected citations for CGS 19755 include:

4 Citations: Showing 1 - 4

  1. N-MthD.-aspartate receptor channel blocker-like discriminative stimulus effects of nitrous oxide gas.
    Authors: Richardson and Shelton
    Cereb Cortex  2015;352:156
  2. Deranged NMDAergic cortico-subthalamic transmission underlies parkinsonian motor deficits.
    Authors: Pan Et al.
    J Pharmacol Exp Ther  2014;124:4629
  3. Potentiation of NMDA receptor-dependent cell responses by extracellular high mobility group box 1 protein.
    Authors: Pedrazzi Et al.
    PLoS One  2012;7:e44518
  4. Neuroprotection associated with alternative splicing of NMDA receptors in rat cortical neurons.
    Authors: Jaekel Et al.
    J Clin Invest  2006;147:622

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