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CHDI 113

Catalog #: 8063
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
8063/5
CHDI 113 | CAS No. 2743336-70-9 | Huntingtin
1 Image
Description: Potent HTT pre-RNA splicing modulator

Chemical Name: 5-[(3R)-3-(Cyclopropylamino)-1-pyrrolidinyl]-N-(8-fluoro-2-methylimidazo[1,2-a]pyridin-6-yl)-2-pyrazinecarboxamide

Purity: ≥98%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Additional Information Product Datasheets Calculators

Biological Activity

CHDI 113 is a potent huntingtin (HTT) pre-mRNA splicing modulator (EC50 = 66 nM). It lowers HTT protein in both human Huntington's disease (HD) stem cells and in the brain of BACHD (bacterial artificial chromosome-mediated transgenic) mouse model. CHDI 113 is brain penetrant and orally bioavailable.

Technical Data

M.Wt:
395.44
Formula:
C20H22FN7O
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2743336-70-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from CHDI Foundation

Product Datasheets

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Citation for CHDI 113

The citations listed below are publications that use Tocris products. Selected citations for CHDI 113 include:

1 Citation: Showing 1 - 1

  1. Identification and optimization of RNA-splicing modulators as Huntingtin protein-lowering agents for the treatment of Huntington's disease.
    Authors: Liu Et al.
    J.Med.Chem.  2024;66:13205

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