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Chloroquine diphosphate

Catalog #: 4109
13 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4109/50
Chloroquine diphosphate | CAS No. 50-63-5 | Antimalarials
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Description: Antimalarial; inhibits apoptosis and autophagy

Chemical Name: N4-(7-Chloro-4-quinolinyl)-N1,N1-dimethyl-1,4-pentanediamine diphosphate salt

Purity: ≥99%

Product Details
Citations (13)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Chloroquine diphosphate is an antimalarial (Plasmodium) medicine. Inhibits cell growth and induces cell death in numerous cancer cell lines; inhibits cell proliferation and viability and induces apoptosis in 4T1 mouse breast cancer cells in vitro. Exhibits antimetastatic activity. Also inhibits autophagy via a mechanism distinct from that of 3-methyladenine (Cat. No. 3977). Blocks receptor-mediated endocytosis of mannose-glycoconjugates by macrophages. Inhibits SARS-CoV-2 infection in vitro (EC50 = 1.13 μM). Chloroquine improves efficacy of adeno-associated viral gene transduction in vivo and in vitro, as well as enhancing non-viral gene transfection in breast cancer cells.

Tocris products are for biomedical research use only. They are not intended for human or veterinary use.

Technical Data

M.Wt:
515.86
Formula:
C18H26ClN3·2H3PO4
Solubility:
Soluble to 100 mM in water
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
50-63-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Antitumor and antimetastatic activities of chloroquine diphosphate in a murine model of breast cancer.
    Jiang et al.
    Biomed.Pharmacother., 2010;64:609
  2. Chloroquine potentiates the anti-cancer effect of 5-fluorouracil on colon cancer cells.
    Sasaki et al.
    BMC Cancer, 2010;10:370
  3. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro.
    Wang et al.
    Cell Research, 2020;30
  4. Chloroquine and ammonium ion inhibit receptor-mediated endocytosis of mannose-glycoconjugates by macrophages: Apparent inhibition of receptor recycling.
    Tietze et al.
    Biochem.Biophys.Res.Commun., 1980;93:1

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Citations for Chloroquine diphosphate

The citations listed below are publications that use Tocris products. Selected citations for Chloroquine diphosphate include:

13 Citations: Showing 1 - 10

  1. A Ubiquitination Cascade Regulating the Integrated Stress Response and Survival in Carcinomas.
    Authors: Lisa D Et al.
    Cancer Discov  2023;13:766-795
  2. A systemic cell stress signal confers neuronal resilience toward oxidative stress in a Hedgehog-dependent manner.
    Authors: Markus D Et al.
    Cell Rep  2022;41:111488
  3. Thrombolysis by PLAT/tPA increases serum free IGF1 leading to a decrease of deleterious autophagy following brain ischemia.
    Authors: Julien Et al.
    Autophagy  2022;18:1297-1317
  4. Imatinib disturbs lysosomal function and morphology and impairs the activity of mTORC1 in human hepatocyte cell lines.
    Authors: Stephan Et al.
    Food Chem Toxicol  2022;162:112869
  5. Pancreatic beta cell autophagy is impaired in type 1 diabetes.
    Authors: Jeroen Et al.
    Diabetologia  2021;64:865-877
  6. Pathogenic GRM7 Mutations Associated with Neurodevelopmental Disorders Impair Axon Outgrowth and Presynaptic Terminal Development.
    Authors: Young Ho Et al.
    J Neurosci  2021;41:2344-2359
  7. Endothelial Tpl2 regulates vascular barrier function via JNK-mediated degradation of claudin-5 promoting neuroinflammation or tumor metastasis.
    Authors: George Et al.
    Cell Rep  2021;35:109168
  8. Metformin Inhibits the Urea Cycle and Reduces Putrescine Generation in Colorectal Cancer Cell Lines.
    Authors: Jing Et al.
    Molecules  2021;26
  9. Alphaherpesvirus-induced activation of plasmacytoid dendritic cells depends on the viral glycoprotein gD and is inhibited by non-infectious light particles.
    Authors: Thomas C Et al.
    PLoS Pathog  2021;17:e1010117
  10. Conserved residues in the extracellular loop 2 regulate Stachel-mediated activation of ADGRG2.
    Authors: Nariman Et al.
    Sci Rep  2021;11:14060

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