CHS 828
Chemical Name: N-[6-(4-Chlorophenoxy)hexyl]-N'-cyano-N''-4-pyridinylguanidine
Purity: ≥98%
Biological Activity
CHS 828 is a NAMPT inhibitor. Decreases cellular level of NAD+. Selectively increases intracellular ROS levels in cancer cells but not normal cells. Active in vivo and cytotoxic.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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CHS 828, a novel pyridyl cyanoguanidine with potent antitumor activity in vitro and in vivo.
Hjarnaa et al.
Cancer Res., 1999;59:5751 -
Nicotinamide phosphoribosyltransferase inhibitor as a novel payload for antibody-drug conjugates.
Karpov et al.
ACS Med.Chem.Lett., 2018;9:838 -
Anticancer agent CHS-828 inhibits cellular synthesis of NAD.
Olesen et al.
Biochem.Biophys.Res.Commun., 2008;367:799
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Citation for CHS 828
The citations listed below are publications that use Tocris products. Selected citations for CHS 828 include:
1 Citation: Showing 1 - 1
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Integrated transcriptomic analysis of human tuberculosis granulomas and a biomimetic model identifies therapeutic targets.
Authors: Rui Et al.
J Clin Invest 2021;131
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