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Ciliobrevin A

Catalog #: 4529
7 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4529/25
4529/5
Ciliobrevin A | CAS No. 302803-72-1 | Hedgehog Signaling Inhibitors
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Description: Hedgehog (Hh) pathway antagonist, inhibits ciliogenesis; also inhibits dynein
Alternative Names: HPI-4

Chemical Name: 2,4-Dichloro-α-(3,4-4-oxo-2(1H)-quinazolinylidene)-β-oxobenzenepropanenitrile

Purity: ≥98%

Product Details
Citations (7)
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Biological Activity

Ciliobrevin A is a Hedgehog (Hh) pathway antagonist; blocks Sonic hedgehog (Shh)-induced Hh pathway activation (IC50 = 7 μM) downstream of Smo. Perturbs primary cilia formation; inhibits cytoplasmic AAA+ ATPase dynein-dependent microtubule gliding and ATPase activity.

Technical Data

M.Wt:
358.18
Formula:
C17H9Cl2N3O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
302803-72-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade.
    Hyman et al.
    Proc.Natl.Acad.Sci.USA, 2009;106:14132
  2. Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein.
    Firestone et al.
    Nature, 2012;484:7392

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Citations for Ciliobrevin A

The citations listed below are publications that use Tocris products. Selected citations for Ciliobrevin A include:

7 Citations: Showing 1 - 7

  1. HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation.
    Authors: Hasan B Et al.
    Science  2020;369
  2. Measles Virus Forms Inclusion Bodies with Properties of Liquid Organelles.
    Authors: Charles E Et al.
    J Virol  2019;93
  3. Primary cilia mediate mitochondrial stress responses to promote dopamine neuron survival in a Parkinson's disease model.
    Authors: Dong-Hyung Et al.
    Cell Death Dis  2019;10:952
  4. Evolutionary modification of AGS protein contributes to formation of micromeres in sea urchins.
    Authors: Poon Et al.
    Nat Commun  2019;10:3779
  5. Receptor-mediated endocytosis generates nanomechanical force reflective of ligand identity and cellular property.
    Authors: Xiao Et al.
    J Cell Physiol  2018;233:5908-5919
  6. ICAM-1 Binding Rhinoviruses A89 and B14 Uncoat in Different Endosomal Compartments.
    Authors: Conzemius Et al.
    J Virol  2016;90:7934
  7. Autophagy Regulates Formation of Primary Cilia in Mefloquine-Treated Cells.
    Authors: Shin Et al.
    Biomol Ther (Seoul)  2015;23:327

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