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cis-Ned 19

Catalog #: 3953
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3953/10
cis-Ned 19 | CAS No. 1137264-00-6 | Calcium Signaling Agents
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Description: NAADP antagonist; inhibits Ca2+ release

Chemical Name: (1S,3S)-1-[3-[[4-(2-Fluorophenyl)piperazin-1-yl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid

Purity: ≥97%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

cis-Ned 19 is an irreversible nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist; inhibits Ca2+ release (IC50 = 800 nM) and [32P]NAADP binding (IC50 = 15 μM). Stereoisomer of trans-Ned 19. Fluorescently labels NAADP receptors in intact cells (excitation 351 and 365 nm using an ultraviolet Argon laser).

Isomer of trans-Ned 19.

Optical Data for cis-Ned 19

λabs 368 nm
λem 425 nm
Closest Laser line 355 nm
Cell Permeable Yes
Application Confocal Microscopy

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Technical Data

M.Wt:
514.59
Formula:
C30H31FN4O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
1137264-00-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Background References

  1. Identification of a chemical probe for NAADP by virtual screening.
    Naylor et al.
    Nat.Chem.Biol., 2009;5:220

Product Datasheets

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Citations for cis-Ned 19

The citations listed below are publications that use Tocris products. Selected citations for cis-Ned 19 include:

2 Citations: Showing 1 - 2

  1. Both RyRs and TPCs are required for NAADP-induced intracellular Ca2+ release.
    Authors: Gerasimenko Et al.
    Sci Rep  2015;58:237
  2. VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel-2-dependent Ca2+ signaling.
    Authors: Favia Et al.
    Proc Natl Acad Sci U S A  2014;111:E4706

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