Clozapine

Key Product Details

Product Description

Clozapine is an atypical antipsychotic drug, with a much lower tendency to cause extrapyramidal side effects than conventional neuroleptics. Displays a broad range of pharmacological actions; the antipsychotic effects are thought to be mediated principally by 5-HT_2A/2C and dopamine receptor blockade (K_i values are 21, 170, 170, 230 and 330 nM for D₄, D₃, D₁, D₂ and D₅ receptors respectively).

Product Specifications for Clozapine

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Clozapine

The following data is based on the product molecular weight 326.83.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

6 5 4 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.06 mL	15.30 mL	30.60 mL
5 mM	0.61 mL	3.06 mL	6.12 mL
10 mM	0.31 mL	1.53 mL	3.06 mL
50 mM	0.06 mL	0.31 mL	0.61 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 181 publications citing the usage of this product.

• Jensen Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-dazepin-3-ol analogues: novel 5-HT2A/5-HT2C receptor agonists with pro-cognitive J.Med.Chem. 2013 PMID: 23301527
• Ellenbroek The involvement of DA D₁ and D₂ receptors in the effects of the classical neuroleptic halope. and the atypical neuroleptic cloz. Eur.J.Pharmacol. 1991 PMID: 1678712
• Seeman and Van Tol DA receptor pharmacology. Trends Pharmacol.Sci. 1994 PMID: 7940991
• Canton Binding of typical and atypical antipsychotics to 5-HT_1C and 5-HT₂ sites: cloz. potently interacts with 5-HT_1C sites. Eur.J.Pharmacol. 1990 PMID: 1982659

Product Documents for Clozapine