Co 101244 hydrochloride

Tocris Bioscience | Catalog # 2456

GluN2B-selective NMDA antagonist
Tocris Bioscience

Key Product Details

Description

GluN2B-selective NMDA antagonist

Alternative Names

PD 174494,Ro 63-1908
View all NMDA Receptor Antagonists »

Product Description

Co 101244 hydrochloride is a novel, potent and selective antagonist of GluN2B (formally NR2B)-containing NMDA receptors (IC50 values are 0.043, > 100 and > 100 μM for GluN1A/2B (NR1A/2B), GluN1A/2A (NR1A/2A) and GluN1A/2C (NR1A/2C) subunit combinations respectively). Displays neuroprotective effects in vivo and in vitro.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Product Specifications for Co 101244 hydrochloride

Molecular Weight

377.91

Formula

C21H27NO3.HCl

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

1-[2-(4-Hydroxyphenoxy)ethyl]-4-[(4-methylphenyl)methyl]-4-piperidinol hydrochloride

CAS Number

193356-17-1

PubChem ID

6918426

InChI Key

WFFZHKKSIDENAJ-UHFFFAOYSA-N

SMILES

Cl.CC1=CC=C(CC2(O)CCN(CCOC3=CC=C(O)C=C3)CC2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 37.79 100
DMSO 18.9 50

Preparing Stock Solutions for Co 101244 hydrochloride

The following data is based on the product molecular weight 377.91.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.65 mL 13.23 mL 26.46 mL
5 mM 0.53 mL 2.65 mL 5.29 mL
10 mM 0.26 mL 1.32 mL 2.65 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

Calculators

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Product Documents for Co 101244 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Co 101244 hydrochloride

For research use only

Citations for Co 101244 hydrochloride

Customer Reviews for Co 101244 hydrochloride (1)

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  • Impact of Co-101244 on current transfer through neutrophil cell membrane
    Name: Sergiy Sylantyev
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Blood
    Verified Customer | Posted 07/13/2023
    Co-101244 was used to quantify the input of GluN2B-containing NMDA receptors into electrical current flow through the membrane of human neutrophil. Figure; normalized electrical response of a single neutrophil after application of Co-101244 (bar +Co).
    Co 101244 hydrochloride 2456

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