Colchicine
Chemical Name: (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide
Purity: ≥98%
Biological Activity
Colchicine is a plant-derived alkaloid that binds to tubulin and depolymerizes microtubules. Identified as a candidate for repurposing for COVID-19. Inhibits NLRP3 inflammasomes. Also decreases TNF-α receptor expression and reduces cytokine levels in macrophages. Anti-inflammatory.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Local translation and retrograde axonal transport of CREB regulates IL-6-induced nociceptive plasticity.
Melemedjian O, Tillu D, Moy J, Asiedu M, Mandell E, Ghosh S, Dussor G, Price T
Mol Pain, 2014;10(0):45. -
High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Analysis of the colchicine-binding site of β-tubulin.
Burns
FEBS Lett., 1992;297:205 -
Identification of cysteine 354 of β-tubulin as part of the binding site for the A ring of colch.
Bai et al.
J.Biol.Chem., 1996;271:12639 -
Interactions of colch. with tubulin.
Hastie
Pharmacol.Ther., 1991;51:377 -
The therapeutic potential of colch in the complications of COVID19. Could the immunometabolic properties of an old and cheap drug help?
Ribeiro et al.
Metabol.Open, 2020;7:100045 -
The NLRP3 inflammasome and the emerging role of colch to inhibit atherosclerosis-associated inflammation.
Martinez et al.
Atherosclerosis, 2018;269:262
Product Datasheets
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Citations for Colchicine
The citations listed below are publications that use Tocris products. Selected citations for Colchicine include:
5 Citations: Showing 1 - 5
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The BTK Inhibitor, Ibrutinib (PCI-32765) Overcomes PacT. Resistance in ABCB1 and ABCC10 Overexpressing Cells and Tumors.
Authors: Zhang
Mol Cancer Ther 2017;16(6):1021
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Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS.
Authors: Park Et al.
Nat Immunol 2016;17:914
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Genetic screening reveals a link between Wnt signaling and antitubulin drugs.
Authors: Khan Et al.
Pharmacogenomics J 2016;16:164
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The small molecule tyrosine kinase inhibitor NVP-BHG712 antagonizes ABCC10-mediated PacT. resistance: a preclinical and pharmacokinetic study.
Authors: Kathawala Et al.
Oncotarget 2015;6:510
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Local translation and retrograde axonal transport of CREB regulates IL-6-induced nociceptive plasticity.
Authors: Melemedjian Et al.
Mol Pain 2014;10:45
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