Home / Complement Signaling inhibitors / Compstatin

Compstatin

Catalog #: 2585
7 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2585/1
Compstatin
1 Image
Description: C3-binding peptide; inhibits complement activation

Purity: ≥95%

Product Details
Citations (7)
Supplemental Products
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Compstatin is a complement inhibitor; binds C3 inhibiting proteolytic cleavage by C3 convertase (IC50 = 28 μM) and activation of classical and alternative complement pathways (IC50 values are 63 and 12 μM respectively). Prolongs graft survival and reduces hyperacute rejection of ex vivo pig kidneys perfused with human blood and inhibits in vivo heparin/protamine-induced complement activation in primates.

Control Peptide also available.

Technical Data

M.Wt:
1550.77
Formula:
C66H99N23O17S2
Sequence:
ICVVQDWGHHRCT

(Modifications: Thr-13 = C-terminal amide, Disulfide bridge: 2-12)

Solubility:
Soluble to 2 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
206645-99-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Background References

  1. Complement component C3 mediates Th1/Th17 polarization in human T-cell activation and cutaneous GVHD.
    Ma Q, Li D, Carreno R, Patenia R, Tsai K, Xydes-Smith M, Alousi A, Champlin R, Sale G, Afshar-Kharghan V
    Bone Marrow Transplant, 2014;49(7):972-6.
  2. Is asthma related to choroidal neovascularization?
    Sun Y, Yu W, Huang L, Hou J, Gong P, Zheng Y, Zhao M, Zhou P, Li X
    PLoS ONE, 2012;7(5):e35415.
  3. Human IgM antibody rHIgM22 promotes phagocytic clearance of myelin debris by microglia
    Y Zorina, J Stricker, AO Caggiano, DC Button
    Sci Rep, 2018;8(1):9392.
  4. CD14(hi)CD16+ monocytes phagocytose antibody-opsonised Plasmodium falciparum infected erythrocytes more efficiently than other monocyte subsets, and require CD16 and complement to do so.
    Zhou J, Feng G, Beeson J, Hogarth P, Rogerson S, Yan Y, Jaworowski A
    BMC Med, 2015;13(0):154.
  5. Inhibition of human complement by a C3-binding peptide isolated from a phage-displayed random peptide library.
    Sahu et al.
    J.Immunol., 1996;157:884
  6. Compstatin, a peptide inhibitor of C3, prolongs survival of ex vivo perfused pig xenografts.
    Fiane et al.
    Xenotransplantation, 1999;6:52
  7. Inhibition of heparin/protamine complex-induced complement activation by compstatin in baboons.
    Soulika et al.
    Clin.Immunol., 2000;96:212

Product Datasheets

COA view current batch
Or select another batch:
View Batch
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for Compstatin

The citations listed below are publications that use Tocris products. Selected citations for Compstatin include:

7 Citations: Showing 1 - 7

  1. Epithelial phenotype restoring drugs suppress macular degeneration phenotypes in an iPSC model.
    Authors: Sharma Et al.
    Nat Commun  2021;12:7293
  2. Evasion of Classical Complement Pathway Activation on Plasmodium falciparum-Infected Erythrocytes Opsonized by PfEMP1-Specific IgG.
    Authors: Larsen Et al.
    Front Immunol  2019;9:3088
  3. The role of platelets in mediating a response to human influenza infection.
    Authors: Koupenova Et al.
    Nat Commun  2019;10:1780
  4. Mesenchymal stem cells infected with Mycoplasma arginini secrete complement C3 to regulate immunoglobulin production in b lymphocytes.
    Authors: Lee Et al.
    Cell Death Dis  2014;5:e1192
  5. Inhibitors of C5 complement enhance vaccinia virus oncolysis.
    Authors: Magge Et al.
    Cancer Gene Ther  2013;20:342
  6. Is asthma related to choroidal neovascularization?
    Authors: Sun Et al.
    Pharmacol Res Perspect  2012;7:e35415
  7. Cardiovascular inflammation and lesion cell apoptosis: a novel connection via the IF.-inducible immunoproteasome.
    Authors: Yang Et al.
    Arterioscler Thromb Vasc Biol  2009;29:1213

FAQs

No product specific FAQs exist for this product, however you may

View all Peptide FAQs

Reviews for Compstatin

There are currently no reviews for this product. Be the first to review Compstatin and earn rewards!

Have you used Compstatin?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.