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Cordycepin

Catalog #: 2294
1 Citation Datasheet / COA / SDS
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Cordycepin | CAS No. 73-03-0 | DNA, RNA and Protein Synthesis Inhibitors
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Description: RNA synthesis inhibitor

Chemical Name: 3'-Deoxyadenosine

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Cordycepin is a nucleoside analog that acts as an anticancer and antifungal agent. Can be converted to 3'-deoxyadenosine triphosphate (3'-dATP), which inhibits ATP-dependent DNA synthesis. Inhibits growth of various tumor cells in vitro.

Technical Data

M.Wt:
251.24
Formula:
C10H13N5O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
73-03-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Cordycepin induces human lung cancer cell apoptosis by inhibiting nitric oxide mediated ERK/Slug signaling pathway
    JH Hwang, SJ Park, WG Ko, SM Kang, DB Lee, J Bang, BJ Park, CB Wee, DJ Kim, IS Jang, JH Ko
    Am J Cancer Res, 2017;7(3):417-432.
  2. The synthesis of 3'-dATP and its use as an inhibitor of ATP-dependent DNA synthesis in toluene-treated Escherichia coli.
    Gumport and Edelhei et al.
    Biochemistry, 1976;15:2804
  3. Antifungal activity of 3'-deoxyadenosine (cordycepin).
    Sugar and McCaffrey
    Antimicrob.Agents Chemother., 1998;42:1424
  4. Antileukemic activity and mechanism of action of cordycepin against terminal deoxynucleotidyl transferase-positive (TdT+) leukemic cells.
    Kodama et al.
    Biochem.Pharmacol., 2000;59:273

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Citation for Cordycepin

The citations listed below are publications that use Tocris products. Selected citations for Cordycepin include:

1 Citation: Showing 1 - 1

  1. Transcription-replication conflicts underlie sensitivity to PARP inhibitors.
    Authors: Petropoulos Et al.
    Nature  2024;628:433

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