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CP 122721 hydrochloride

Catalog #: 3649 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3649/25
3649/5
CP 122721 hydrochloride | CAS No. 145877-52-7 | NK1 Receptor Antagonists
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Description: High affinity NK1 antagonist

Chemical Name: (2S,3S)-N-[[2-Methoxy-5-(trifluoromethoxy)phenyl]methyl]-2-phenyl-3-piperidinamine dihydrochloride

Purity: ≥98%

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Biological Activity

CP 122721 hydrochloride is a high affinity NK1 antagonist (pIC50 = 9.8). Suppresses recruitment of immunocytes in respiratory syncytial virus (RSV)-infected rats after capsaicin stimulation. Also blocks substance P-induced excitation of locus ceruleus cells in guinea pig brain slices (IC50 = 7 nM). Exhibits anxiolytic and antidepressant-like effects. Active in vivo.

Technical Data

M.Wt:
453.33
Formula:
C20H23F3N2O2.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
145877-52-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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