Home / CRF1 Receptor Antagonists / CP 154526

CP 154526

Catalog #: 2779
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2779/10
2779/50
CP 154526 | CAS No. 257639-98-8 | CRF1 Receptor Antagonists
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Description: Selective, non-peptide CRF1 antagonist

Chemical Name: N-Butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride

Purity: ≥99%

Product Details
Citations (1)
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Biological Activity

CP 154526 is a selective, non-peptide CRF1 receptor antagonist (Ki values are 2.7 and > 10000 nM for CRF1 and CRF2 receptors respectively). Blocks CRF-induced adenylate cyclase activation (Ki = 3.7 nM) and attenuates activation of the HPA axis by CRF. Displays anxiolytic-like activity in the rat elevated plus-maze test; brain penetrant.

Technical Data

M.Wt:
400.99
Formula:
C23H32N4.HCl
Solubility:
Soluble to 50 mM in DMSO and to 50 mM in ethanol
Purity:
≥99%
Storage:
Desiccate at +4°C
CAS No:
257639-98-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

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Citation for CP 154526

The citations listed below are publications that use Tocris products. Selected citations for CP 154526 include:

1 Citation: Showing 1 - 1

  1. CRF-R1 activation in the anterior-dorsal BNST induces maternal neglect in lactating rats via an HPA axis-independent central mechanism.
    Authors: Klampfl Et al.
    Biochem Biophys Res Commun  2016;64:89

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