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CST 626

Catalog #: 8021 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
8021/2
CST 626 | Active Degraders
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Description: Potent pan IAP Degrader (PROTAC®)

Chemical Name: (2S,4S)-1-((S)-2-Cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)-4-(3-((5-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-5-oxopentyl)oxy)phenoxy)-N-((R)-1,2,3,4-tetrahydronaphthalen-1-yl)pyrrolidine-2-carboxamide

Purity: ≥98%

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Biological Activity

CST 626 is a potent IAP Degrader (PROTAC®) (DC50 values at 16 hours are 0.7 nM, 2.4 nM and 6.2 nM at XIAP, cIAP1 and cIAP2 respectively; Dmax = 90-99%). Reduces cell viability in some cell types, including SUDHL6 and MOLM13 (IC50 values are 16 nM and 21 nM respectively).

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data

M.Wt:
1103.43
Formula:
C61H82N8O9S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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