Home / Toll-like Receptor Inhibitors / CU CPT 9a

CU CPT 9a

Catalog #: 6479 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6479/5
6479/25
CU CPT 9a | CAS No. 2165340-32-7 | Toll-like Receptor Inhibitors
1 Image
Description: Highly potent TLR8 inhibitor

Chemical Name: 2-Methyl-4-(7-methoxy-4-quinolinyl)phenol

Purity: ≥98%

Product Details
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

CU CPT 9a is a potent TLR8 inhibitor (IC50 = 0.5 nM and Kd = 21 nM). Stabilizes the TLR8 dimer in its resting state, preventing activation. Suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells.

Technical Data

M.Wt:
265.31
Formula:
C17H15NO2
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2165340-32-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from the University of Colorado

Background References

  1. Small-molecule inhibition of TLR8 through stabilization of its resting state.
    Zhang et al.
    Nat.Chem.Biol., 2018;14:58

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for CU CPT 9a

There are currently no reviews for this product. Be the first to review CU CPT 9a and earn rewards!

Have you used CU CPT 9a?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.