CVT 313
Chemical Name: 2,2'-[[6-[[(4-Methoxyphenyl)methyl]amino]-9-(1-methylethyl)-9H-purin-2-yl]imino]bis[ethanol]
Purity: ≥98%
Biological Activity
CVT 313 is a cyclin-dependent kinase 2 (cdk2) inhibitor (reported IC50 values are 0.18 to 0.5 μM). Also inhibits cdk5 in sub-micromolar range (IC50 = 0.42 μM). Displays >7-fold selectivity for cdk2 and cdk5 over other cdks. Inhibits proliferation rat neonatal aortic smooth muscle cells and a range of tumor cells lines in vitro. Inhibits restenosis in a rat carotid artery injury model.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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CVT-313, a specific and potent inhibitor of CDK2 that prevents neointimal proliferation.
Brooks et al.
J.Biol.Chem., 1997;272:29207 -
How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases?
Jorda et al.
J.Med.Chem., 2018;61:9105
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Citation for CVT 313
The citations listed below are publications that use Tocris products. Selected citations for CVT 313 include:
1 Citation: Showing 1 - 1
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Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes.
Authors: Musa Et al.
Nat Commun 2019;10:4128
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