Cyclotraxin B
Purity: ≥95%
Biological Activity
Cyclotraxin B is an antagonist of TrkB receptors; inhibits BDNF-induced TrkB activity (IC50 = 0.30 nM). Allosterically alters TrkB receptor conformation but does not alter BDNF binding. Prevents BDNF-induced cold allodynia in mice. Also shown to exhibit putative anxiolytic properties in mice.Technical Data
(Modification: Disulfide bridge: 1-11)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Cyclotraxin-B, a new TrkB antagonist, and glial blockade by propentofylline, equally prevent and reverse cold allodynia induced by BDNF or partial infraorbital nerve constriction in mice.
Constandil et al.
J.Pain, 2012;13:579 -
Cyclotraxin-B, the first highly potent and selective TrkB antagonist, has anxiolytic properties in mice.
Cazorla et al.
PLoS One, 2010;5:e9777
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Citations for Cyclotraxin B
The citations listed below are publications that use Tocris products. Selected citations for Cyclotraxin B include:
2 Citations: Showing 1 - 2
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Opposing Effects of CREBBP Mutations Govern the Phenotype of Rubinstein-Taybi Syndrome and Adult SHH Medulloblastoma.
Authors: Merk Et al.
Dev Cell 2018;44:709
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BDNF interacts with endocannabinoids to regulate cocaine-induced synaptic plasticity in mouse midbrain DA neurons.
Authors: Zhong Et al.
Oncotarget 2015;35:4469
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