CYM 50358 hydrochloride
Chemical Name: N-[(4-(Aminomethyl)-2,6-dimethylphenyl]-5-(2,5-dichlorophenyl)-2-furancarboxamide hydrochloride
Purity: ≥97%
Biological Activity
CYM 50358 hydrochloride is a potent S1P4 antagonist (IC50 = 25 nM). Displays selectivity for S1P4 against S1P1, S1P2, S1P3 and S1P5 receptors.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Human Naive and Memory T Cells Display Opposite Migratory Responses to Sphingosine-1 Phosphate
A Drouillard, A Neyra, AL Mathieu, A Marçais, M Wencker, J Marvel, A Belot, T Walzer
J. Immunol., 2017;0(0):. -
Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P4) receptor antagonists.
Guerrero et al.
Bioorg.Med.Chem.Lett., 2011;21:3632 -
TGFβ1 evokes myoblast apoptotic response via a novel signaling pathway involving S1P4 transactivation upstream of Rho-kinase-2 activation.
Cencetti et al.
FASEB J., 2013;27:4532
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Citations for CYM 50358 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for CYM 50358 hydrochloride include:
2 Citations: Showing 1 - 2
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Inhibition of sphingosine-1-phosphate receptor 3 suppresses ATP-induced NLRP3 inflammasome activation in macrophages via TWIK2-mediated potassium efflux.
Authors: Chen Et al.
Front Immunol 2023;14:1090202
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Interferon gamma constrains type 2 lymphocyte niche boundaries during mixed inflammation.
Authors: Richard M Et al.
Immunity 2022;55:254-271.e7
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