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D-CPP-ene

Catalog #: 1265
2 Citations Datasheet / COA / SDS
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D-CPP-ene | CAS No. 117414-74-1 | NMDA Receptor Antagonists
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Description: Potent competitive NMDA antagonist
Alternative Names: Midafotel,SDZ EAA 494

Chemical Name: D-4-[(2E)-3-Phosphono-2-propenyl]-2-piperazinecarboxylic acid

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Citations (2)
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Biological Activity

D-CPP-ene is a potent and competitive NMDA antagonist (Ki = 40 nM). Centrally active following systemic administration.

Technical Data

M.Wt:
250.19
Formula:
C8H15N2O5P
Solubility:
Soluble to 100 mM in water
Storage:
Desiccate at RT
CAS No:
117414-74-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. D-CPP-ene (SDZ EAA 494), a potent and competitive N-MthD.-aspartate (NMDA) antagonist: effect on spontaneous activity and NMDA-induced depolarizations in the rat neocortical slice preparation, compared with other CPP derivatives and MK-801.
    Lowe et al.
    Neurosci.Lett., 1990;113:315
  2. Effects of the NMDA receptor antagonist D-CPPene on extracellular levels of DA and DA and serotonin metabolites in striatum of kindled and non-kindled rats.
    Potschka et al.
    Eur.J.Pharmacol., 1999;374:175
  3. Synthesis and NMDA antagonistic properties of the enantiomers of 4-(3-phosphonopropyl)piperazine-2-carboxylic acid (CPP) and of the unsaturated analogue (E)-4-(3-phosphono-2-enyl)piperazine-2-carboxylic acid (CPP-ene).
    Aebischer et al.
    Helv.Chim.Acta, 1989;72:1043

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Citations for D-CPP-ene

The citations listed below are publications that use Tocris products. Selected citations for D-CPP-ene include:

2 Citations: Showing 1 - 2

  1. ATM and ATR play complementary roles in the behavior of excitatory and inhibitory vesicle populations.
    Authors: Cheng Et al.
    Proc Natl Acad Sci U S A  2018;115:E292
  2. NMDA-type glutamate receptors participate in reduction of food intake following hindbrain melanocortin receptor activation.
    Authors: Campos and Ritter
    Oncogene  2015;308:R1

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