Home / Ghrelin Receptor Antagonists / [D-Lys3]-GHRP-6

[D-Lys3]-GHRP-6

Catalog #: 1922
6 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1922/5
[D-Lys3]-GHRP-6
1 Image
Description: Ghrelin receptor antagonist

Purity: ≥95%

Product Details
Citations (6)
Supplemental Products
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

[D-Lys3]-GHRP-6 is an antagonist at the ghrelin receptor (GHS-R1a) (IC50 = 0.9 μM). Also weakly binds to melanocortin receptors (Ki = 26-120 μM). Centrally active in vivo.

Technical Data

M.Wt:
930.12
Formula:
C49H63N13O6
Sequence:
HWKWFK

(Modifications: Trp-2 = D-Trp, Lys-3 = D-Lys, Phe-5 = D-Phe, Lys-6 = C-terminal amide)

Solubility:
Soluble to 0.50 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
136054-22-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Nutritional state-dependent ghrelin activation of vasopressin neurons via retrograde trans-neuronal-glial stimulation of excitatory GABA circuits.
    Haam J, Halmos K, Di S, Tasker J
    J Neurosci, 2014;34(18):6201-13.
  2. Devil's Claw to suppress appetite--ghrelin receptor modulation potential of a Harpagophytum procumbens root extract.
    Torres-Fuentes C, Theeuwes W, McMullen M, McMullen A, Dinan T, Cryan J, Schellekens H
    PLoS ONE, 2014;9(7):e103118.
  3. Antinociceptive Effect of Ghrelin in a Rat Model of Irritable Bowel Syndrome Involves TRPV1/Opioid Systems
    Y Mao, Z Li, K Chen, H Yu, S Zhang, M Jiang, Y Ma, C Liang, H Liu, H Li, Q Hua, H Zhou, Y Sun, X Fan
    Cell. Physiol. Biochem., 2017;43(2):518-530.
  4. Characterization of the binding of MSH-B, HP-228, GHRP-6 and 153N-6 to the human melanocortin receptor subtypes.
    Schioth et al.
    Neuropeptides, 1997;31:565
  5. Ghrelin acts on leptin-responsive neurones in the rat arcuate nucleus.
    Traebert et al.
    J.Neuroendocrinol., 2002;14:580
  6. Role of ghrelin in the control of GH secretion in prepubertal rats: interactions with excitatory amino acids.
    Pinilla et al.
    Neuroendocrinology, 2003;77:83

Product Datasheets

COA view current batch
Or select another batch:
View Batch
SDS
Reconstitution Calculator
Molarity Calculator

Citations for [D-Lys3]-GHRP-6

The citations listed below are publications that use Tocris products. Selected citations for [D-Lys3]-GHRP-6 include:

6 Citations: Showing 1 - 6

  1. Endogenous ghrelin-O-acyltransferase (GOAT) acylates local ghrelin in the hippocampus.
    Authors: Murtuza and Isokawa
    J Neurochem  2018;144:58
  2. Rikkunshito prevents PacT.-induced peripheral neuropathy through the suppression of the nuclear factor kappa B (NFκB) phosphorylation in spinal cord of mice.
    Authors: Kamei Et al.
    PLoS One  2017;12:e0171819
  3. Direct versus indirect actions of ghrelin on hypothalamic NPY neurons.
    Authors: Hashiguchi
    PLoS One  2017;12(9):e0184261
  4. The effects of ghrelin antagonists [D-Lys(3) ]-GHRP-6 or JMV2959 on ethanol, water, and food intake in C57BL/6J mice.
    Authors: Gomez and
    Alcohol Clin Exp Res  2014;38:2436
  5. Ghrelin modulates lateral amygdala neuronal firing and blocks acquisition for conditioned taste aversion.
    Authors: Song Et al.
    PLoS One  2013;8:e65422
  6. Intrarenal ghrelin infusion stimulates distal nephron-dependent sodium reabsorption in normal rats.
    Authors: Kemp Et al.
    PLoS Comput Biol  2011;57:633

FAQs

No product specific FAQs exist for this product, however you may

View all Peptide FAQs

Reviews for [D-Lys3]-GHRP-6

There are currently no reviews for this product. Be the first to review [D-Lys3]-GHRP-6 and earn rewards!

Have you used [D-Lys3]-GHRP-6?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.