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[D-Trp34]-Neuropeptide Y

Catalog #: 3436 Datasheet / COA / SDS

Discontinued Product

3436 has been discontinued.
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[D-Trp34]-Neuropeptide Y
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Description: Potent NPY Y5 agonist; orexigenic
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Biological Activity

[D-Trp34]-Neuropeptide Y is a potent neuropeptide Y (NPY) Y5 receptor agonist (pEC50 values are 7.82, 6.28, 6.44 and > 6 at rat Y5, Y4, Y1 and Y2 receptors respectively) that displays > 26-fold, > 1000-fold and > 1000-fold selectivity over Y1, Y2 and Y4 receptors respectively. Induces hyperphagia, body weight gain, adiposity, hypercholesterolemia, hyperinsulinemia and hyperleptinemia in vivo. Orally active.

Technical Data

M.Wt:
4311.77
Formula:
C196H289N55O56
Sequence:
YPSKPDNPGEDAPAEDLARYYSALRHYINLITRWRY

(Modifications: Trp-34 = D-Trp, Tyr-36 = C-terminal amide)

Solubility:
Soluble to 0.20 mg/ml in 20% acetonitrile
Storage:
Store at -20°C
CAS No:
153549-84-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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